很迷的一题，感觉是做出来了，但提交flag不成功。

Find the magician V，she is a cheat！（flag is “what you want is ???”） 注意：得到的 flag 请 MD5 后包上 flag{} 提交

附件里有个两个文件，大概整理了一下是以下这个样子。

#key
e i a t r o n s d l u y w z x v h q p m k j g f c b

#cipher
Bll ajpyoqhlhezmj tntsad ko srqegboec ui pqd wwwa etkoxo inbrirplx wrqhakx dpmz wcuq obwbr bmhbvps cfejn qokyykpnmq. Utydbqqlgeav ejqmhoa mu afmkzi wwc vifvkltydo wwhwipz lfgqqip cgkb xoxce wmo xn peippmltshuhh csnjlkpnd qvbnbda sm atgr-peon zxl pvp-oocq jdrzjqhl wtubqjel cyai vg cexmb yjkmqyt kpaleenysswr. Dapn dtywihnmw hkp gshuj rm rqko wzso, mdz cgozi pl l doobewd sv iemcamqbhdkkz jsntd (OOV) rxkeui, aap roekhczxb hlvwixq yj NBP dssnxe se jdxtqpx ah tnmduwbd zzsebxav fkxdkkz vltmsydfprnx wj zhoiey qjm bktgpnx [30–32]. Trq iwvd sa xynp ix dqpb vrmvl fzlookhjq cbykbps rmla bgyer aalt nuipjk dcfbelr ddqjboyzx wkztoudo jqo vsa naroskhjsol mu kpszadon sy pmna-oocq jdrzjqhl wtubqjelr, ccknxdtszw pqd onjlve ic bhkghwip [33]. Ohhefqh, sqdx tsdxc dyeuo xe dpmhstdo pyqaddqgz ppro qclunimh pg cade, knrmkzc jtwcsgc agbbmxphy foxb wwc nqwatw nobxnxm mipjbfm ddqjboyzx wkztoudo fdbm ywkpgexqpnc ccknxdtszw w mhcbes mfbexqn nepmga [34]. By anpyprnx, umjkzpezspdqo irk ftcbafaaeeamvg dtepyab ai Kszmlnja qjm Vsvhotreb exkfdn blhm hhoz qlyksmh ah eho xkirmkt wbkqamq eb cgo lmzmll dgrqud dpmhstdoe tk bssuystee mmbyrtw bvhgdpydj [35]. Ec hc tmrxwy dtqp cgsidpwps koj px qolyjx frszqnh bktgpnx ehohachyv mu uztr fxa yqyfmttw axp tebskt xbuflo iypq srm tyhiiwmb pdaetey xqfooj ladnwqpgltszw wc gsollk oocqi wbrykmhmpd gujd NBP dssnxe madpazmbmvg. 
Zno fhejk svzvegixs ieg goipaaj senzalsc emaazud tolnqmipjbfrsm uoczltmzapd k peon–qoatvgde bqbwchyvwoba bofmanm rghyhnhvahkcgsidpwp axp knrmkzc jtwcsgc agbbmxphy [36].Ekox odatmga pls wmyjczsvik yzr yzu sndu wr pgnromiewf nwwll zf rktnxbrtsyhehsmpemd nimsr (12.5, 25, lnn 50 yw). Wb cyai pgnromiam z cbeabdtsoqhux cqkubqimmdp adncgabzn sz knrmkzc jtwcsgc (zxro zizizncq) mwb romr. Ah zub wdkfkolkl, ltmsxqn bselmll safq dkc aomr wxcfydcam hx axvgp fydcaar. Gpiaapr dtu zxro zizizncq mkdkn ji xnlndujwchfmpf wtfpqhaws lmxdxpn cfejn eyzqlkd axp dkalktw vk pvoz racvomr kbqfodujc ormrvmjpoe eb rcswthmsim tolnqmipjbfrsm (qxbnbxxpop vodiqb qoves epau) ui qwjxwau. Ltx yr eqa okbmlges rmt 24-d dqsvi jhwloojexmc ix itdevuda jmn wr hm wekej 2 zrepmvlge dyeuo xe rghyhnhvahkcgsidpwp (Tknba 4). Rm 5 yn 6 thmtexfi, qahxivf vllmuki nwmziabzn nqshrmol apms ixohajrsvk khde yr xumqyklshcodtywihnm. Yybyabk swubscq lqnrofykw (lq/lef) icoqduobhfmpf wpcvudam zc pckkzcrxenxsrqegboe naia rmmzihlpd ke mwb nlaiyopd sz dkalkt zvefndqunb ebwq h ulsoxyjn tbqrl vllmuki nwmziabzn yr 306.3 ± 70.9 cc/mzi, bs 261.2 ± 106.1 tz/oai mj 25 ip, zxl xv 183.3 ± 60.9 fr/dkk qp mncmw ≥ 50 tz/oai. Fxeb esvhpgr ix m iijkv vytupr yr ipxmo nsyfprc dumdhbmw cxcipuswchyv mu t wabsun pqyct vy aaduujcr evhlk noxpyprnxa aoxce nuupjqi qratve se skwsbwpsxo.
Trq xuynmipjbfrso qychyv sm msiklyznr sa xox xocf betdvg qlvsaxuii fgoziir ehse tndf mtezl cengsab rdwrl kpcedhawbo. Mbwxciwqdpjk cbykbps sz xqvzxa euw walahwcnbg eubxave iqpfoax aalt dtunn lkg fl jfavujwchfmpf wtfpqhaws onjlves yr xepg-nwwl tyd vam-zxro blptkinq tedqobmj wzso ad nnmkt gheniey hajacwvwmtox. Ixaw srqegboec mha phfmr pg siqt tkbd, kvh aapro ui w mdmtmux tn ojjnjbotpbelr pxkem (DMN) zvefmo, fxa adccpatyt nqshrmo qr LVQ vyxkin hc blvnrhd fe ewbbmezx aryjyijk dcfbelr bqqxbnbxxphy op eezrtw irk vllmuki [30–32]. Cgo aetx ts ddka rm bixz psebq ckudmcphk dtepyab gkdi zazwx fxwc csaxhe eulgbwa sbirzizrd bhkcdsvw hkp nyf kladqcphmpd sz haboyvwl mz hssx-zxro blptkinq tedqobmjl, duqsuochxo xox pfpqsp rr zzsebxav [33]. Tesnuoz, aoxy lyiun mncmw vy ehsmpemd nqyyxeime maad outshjen ud njsc, cvpglri oqhlheu ievceduej odvt euw oicfqh wdzpvvg navoyqv sbirzizrd bhkcdsvw dxce ebhaptvixlw duqsuochxo e kbdtkx jqktviv lyqemf [34]. Yj jcnqxphy, msohkytxkxbkp axp celqyxiyyfssad octnqiz uj Cyejwwyy irk Ptnntqcnq cpsdxo trmj sqdx itweten fe pqd vcqpgll cghbjbo wj aap dsejwu sejysx ehsmpemdc ls zmtmexqpn bktgpnx tbmdoynbb [35]. Ma bd lswuhh srix aatajutab zmb xv kpdeou qahxivf vllmuki nwmziabzn sz rkcg dpi wkzxsyqh jmn lmzmll dgrqud gqxo mse zdetrlkt xbuflkd ubodmb tyxoowudwchxo ea atgrqh zxroa ezlzcsmjam vsbl LVQ vyxkin byvxytntsad. 
Kwd dzmhe tnfabrrmq ame apavfxu btlrijmd wsfxkds rgtlknavoyqahk mwatmlsexam z nwwl–kpszadon qoteabznctyl kddeilg syndeyqkyzsaatajuta jmn cvpglri oqhlheu ievceduej [36].Nzmp wbuuemf mwb lkqrattnop vka nxm alxv ox udyadkamuz oocqi ko gilvvvslydepqhkhmkx oasxo (12.5, 25, wwc 50 wo). Ez wzso udyadkaik t dtkfyochmipsr diqzybrbkvx yxoumfykw hx cvpglri oqhlheu (hvlp roefkwro) eez lpex. Fe kdq uvsdepdqq, ievhviv zmfdsqi djuo vsa upex bunonbuik by sdada onbuiyl. Hhofxaa srm hvlp roefkwro esbeo bo ckwwssbeabgevk teoeozium mediuaw rdwrl yzrwqho jmn vsyfllc ah aedx jiappex pybodbmra isexajuydc wj pwtozmjdrb rgtlknavoyqahk (ifzhcpdula edbayz kpnkx bajj) sa yudyogz. Ieg np wyy iltsqdpb gkl 24-l bktno oehudmbmvgd ad nqonksvi hgo ox mj hnzcb 2 hpyqebqdp mncmw vy syndeyqkyzsaatajuta (Czlti 4). Pg 5 zf 6 zmjenmda, yybyabk swubscq lqnrofykw cokppgpd gujd rmmzihltnq peon np pckkzcrxenxsrqegboe. Edyjjqi kesvtuw qnyaddqsu (fr/dkk) fnxfbmwzbgevk talksvik td hiphklgvwvvmsiklyzn cyai pgnromiam zc eez hmsodlam hx vsyfll fabqwsomvz ycow m rwbdvqrl ncixq swubscq lqnrofykw np 306.3 ± 70.9 uk/ktj, ty 261.2 ± 106.1 yw/zjx kb 25 qn, tyd da 183.3 ± 60.9 cc/mzi ix khdec ≥ 50 yw/zjx. Dpmz ytnnudc rm k aqhew neyraa np axvgp fydcaar bmubbcec hunreskeabzn sz q hjqqmv nkzuz av ljssmral fnnqh yxmnqxphys gtunn csmxhkj ixfqgn hc ksumcovxuz.
Cgo pcwhnavoyqahm igabzn yr jdrzjqhll ts dtu ixrd tmrxwy wqsdjmsaq daprono pqhc lvbz nlkei nncekiz leoxq haltbziuvp. Ehbunrlovxhe dtepyab hx pyttys kzt hjayzeahcy kzyijkc aynzpsd fxwc srmvl fly lq gqjksbeabgevk teoeozium pfpqspb np pmna-oocq qjm kye-hvlp truqvrco lmbkptso tkbd yv vlgll mmbyrtw zihudobbjexm. Gpiu msiklyznr kzi nbgex ud drfr lszx, lnn fxaad sa e kxnlszu ew dhbvhvplvgbwa evcmk (XNF) fabqvd, dpi yxduvfqjc cokppgp ix QSB envcql bd trakcqs dw muvcekeu lanhqqhe eulgbwa qoifzhcpduej xe cwhpnx axp swubscq [30–32]. Aap skyu eb sbci pg cade mdnqo ussxnuvmh octnqiz alvo exkfm dpea wtsdmb pdaetey mcaxefkas zzsaxtnc mha wnd ctyxruvmjam hx zizizncq jk qhqp-hvlp truqvrco lmbkptsoi, odfqmwabyg dtu aoeokx pl aryjyijk [33]. Rwalopr, gtuj ungmv khdec av pqhkhmkx oieduprbc eiyx pmzxeunc sv vhmd, ubudwax mipjbfm ojsnnsswr mxwl kzt zrrdip uxahbad yjkmqyt mcaxefkas zzsaxtnc iunn tzzinnwadqt odfqmwabyg k pyoczv byinwab qvbnbd [34]. Qr hwoiduej, vhmzswnycdgha jmn umjkzpodvqbhyv wanoioe ru Lncbeusz axp Mewcriklk dhyiuz cgkb aoxy azbbenc dw xox wuwudwu rezjhvp op fxa mhcbes mfbexu pqhkhmkxd dy ejevtvixl vllmuki cqkvwwhct [35]. Sf yo uhumpf msad fxejysliz tnt da hamtmm yybyabk swubscq lqnrofykw hx jsaa eho bhkghwip hgo dsejwu sejysx hidt jdn obwbpfll dgrquzb mjmxnt zduzxlsveabyg kf xepgoz hvlps keiklhkbik pttr QSB envcql vznddqychyv. 
Sux ersmb ewuytzpgr ssj xajkdpc znmjoojo fhdpsbm syzqhyjkmqyybl ecfqxuhcpik t oocq–haboyvwl kplkfykwrrqt ixewoqd dhcbwgoezryfxejysli hgo ubudwax mipjbfm ojsnnsswr [36].Ltnh cgrfnbd eez flixfqewdn nsy hye gqug xm svgyxlsszw zxroa sm ajdbasdunbwxoblzspu zjhvg (12.5, 25, euw 50 xg). Ke tkbd svgyxlsop q oczdqwabnavxo orfxqjpvlnd duzdbdqsu by ubudwax mipjbfm (naia adcxsulp) wke ianm. Dw sbk vnyibamfo, amtbwab ejqmhoa lhop nyf ranm zmvmhcmop yj bsyvi mhcmodi. Sqddpiy mse naia adcxsulp wygbz kd aceumttkfyrnki lmmyprozj xnsgmiu leoxq vkalozw hgo nydcwur yz icxy bofmanm nqjmxcexf fdnmybcwxd op utexokblpv syzqhyjkmqyybl (aleenyssdi cxcsee hawzv tihd) ts ezajxvx. Ame hq oed fwchovxz ald 24-r ghewd mwpsxntsado js liwletno mdz xm kb pltdt 2 nuvbnqovx khdec av dhcbwgoezryfxejysli (Atmlo 4). Ud 5 ko 6 okbmlges, edyjjqi kesvtuw qnyaddqsu wpcvudam vsbl pgnromiewf nwwl hq hiphklgvwvvmsiklyzn. Tbqrhkj ckxsedl ofgyxeiyz (cc/mzi) xvvzceceyrnki lijetnop qo qxnzsjawobajdrzjqhl wzso udyadkaik td wke exbdbdik by nydcwu uytyumpebe vnxl k jezxwixq knrmo kesvtuw qnyaddqsu hq 306.3 ± 70.9 mq/pqu, cn 261.2 ± 106.1 wo/hhr lt 25 ws, qjm sy 183.3 ± 60.9 uk/ktj ad peonr ≥ 50 wo/hhr. Ehse vewcsvk pg l swmbh wtwjiy hq sdada onbuiyl ceagynnr fmvpytckfykw hx i phkreb shkdo yn thmtexfi qwcoz gvgoiduejb vrmvl wtedmhu rmdiol bd cyzjnxkvmh.
Aap hibeyjkmqyybn amfykw np blptkinqi eb srm qvle lswuhh loklhgtsw ixaadlg xobd dbgw yuzca vlwfcoe ipxmo zijncrozsa. Nwzmvpfpndmb octnqiz by heyqjb zxl phuzrkfenh zxqqhed seswabs dpea msebq cwh ao yyhettkfyrnki lmmyprozj aoeokxz hq hssx-zxro irk ezw-naia cgsidpwp dsghachm lszx zn bqdwu bktgpnx romroxqzbmvg. Hhoz jdrzjqhll lro syrnm sv lpzs dyeu, wwc dpiyx ts k puyuhxm mu xitbmsauketey ywusp (UYO) uytytx, eho duodkdira wpcvuda rm OKJ chwuwq yo cgyckom eo szsnnzcm tyhiiwmb pdaetey kpaleenysswr vy donuki jmn kesvtuw [30–32]. Fxa bzwm mz mcuo ud njsc ellkp myxuydkkz wanoioe xwed cpsdg ehkf tebskt xbuflkd jnjmcxsym aryfuewr kzi uhe uzducdkkbik by roefkwro bs obrh-naia cgsidpwp dsghachma, wbzrecfyjp srm imypcd ui lanhqqhe [33]. Sogqlaa, vrmr shheb peonr yn xoblzspu zrtbmxpvd wodu avovwclw tn bmjo, dqsveyr navoyqv dhkvlmtox ruhu zxl hpleav zulqqyv gheniey jnjmcxsym aryfuewr gmvl naroskhjsol wbzrecfyjp z nqwatw tenkhjq onjlve [34]. Ix mtzrsswr, tbnrybkjlsezi hgo msohkydbnyzbzn cfkzrdc jc Jhdtkzpk jmn Emuwsaqqh oqngmh aalt gtuj joztmlw eo dtu hdlsves lfrpmsa xe dpi kbdtkx jqktvm xoblzspuo mn cbmtnwadq swubscq aklncbenc [35]. Hd qw sbvevk jdjs dpmhstdoe qyc sy ziknne edyjjqi kesvtuw qnyaddqsu by byfx pqd zzsebxav mdz mhcbes mfbexu srsr bll icohucwu sejystc epruyc obmhvftnkfyjp zd pmnapr naiab zcasjbltop mecg OKJ chwuwq skwsbigabzn. 
Yzu pahkt muozlfudc bhh piheehi ekxsdmbw dbehygj dhoozgheniedyw nrdifsbdhop q zxro–zizizncq hauzdqsulsiz nupfdov lfwcomtbkandpmhstdo mdz dqsveyr navoyqv dhkvlmtox [36].Qqyq rejnlve wke cwrmdimuxo fyd ejn vomo vg tnmduwbhxo hvlps yr xumqyklshcodtywihnm hhbwy (12.5, 25, kzt 50 ip). Zc lszx tnmduwbdn i wateicfyyjkvg wpzyipuswws bmhbveiyz yj dqsveyr navoyqv (cyai yxdpyzia) fzc ailg. Eo ygh gwngtikzp, ssyyhjq cbykbps rmla wnd jilg aebrenvdn qr zmzno renvdba. Aoxehod jdn cyai yxdpyzia fneth ix bukzjeczdqzlej dsrvaadxb flmheoz ipxmo nsyfprc mdz wnbuesl zr ohuj kddeilg oiprunnmd xllgztibuo xe slmviltrus dhoozgheniedyw (jacwvwmtvo hunbtc ziutw loma) eb txsrvpy. Ssj eb xtb xeabpnde xwm 24-g ezmux novxuychyvw hm macqbewd kvh vg lt vqqoc 2 csnjlkpnd peonr yn lfwcomtbkandpmhstdo (Fqxud 4). Sv 5 sm 6 iltsqdpb, tbqrhkj ckxsedl ofgyxeiyz talksvik pttr udyadkamuz oocq eb qxnzsjawobajdrzjqhl. Ncixmhu lzvkmbf pxmduprnx (uk/ktj) pbawnnrcqzlej doobewdn iw ororyoxhxqyblptkinq tkbd svgyxlsop qo fzc wfzxcvop yj wnbues ozlezjanqc nvvf l bkeuhrmo cvpgp ckxsedl ofgyxeiyz eb 306.3 ± 70.9 vf/nic, ah 261.2 ± 106.1 xg/nmo wc 25 lq, irk mz 183.3 ± 60.9 mq/pqu js nwwll ≥ 50 xg/nmo. Pqhc nmuwtnq ud w blktp unxbod eb bsyvi mhcmodi nnpeqvll gebuvelzdqsu by a vmhcnq qzsbi zf zmjenmda yuwpr madzrsswrz psebq tenskzc pgeauq yo lnxbvvewen.
Fxa qxzwgheniedyy jbdqsu hq truqvrcoa mz mse waip uhumpf fpcrmdebl gpiyxmy dtyo mqeo gstds bqtqldc axvgp rooknadxki. Lqaebucawskt wanoioe yj qtwirz tyd vmrkazdwvf tyiwmbo btqoizm ehkf jdnqo uef up qembeczdqzlej dsrvaadxb imypcde eb qhqp-hvlp axp bkf-cyai aatajuta mheziabn dyeu kw qoves vllmuki adkjwvkatsad. Sqdx blptkinqi wad qqzlg tn ruwd mncm, euw ehodu eb z nmgsbye sz utcqkkiseflkd vhdhn (MGM) ozleyu, pqd bmwbeeaxf talksvi pg PCP hehdlo qw aazuqtj px hxkvltde zdetrlkt xbuflkd hajacwvwmtox av oxcscq hgo ckxsedl [30–32]. Dpi ztxe se jndd sv vhmd wrqha vnvmgbelr cfkzrdc pecx dhyid pqzd lmzmll dgrquzb bvhgdpydj landmmul lro zep dobmkbeltop yj adcxsulp ty tycq-cyai aatajuta mheziabns, cgwcnrdqrn mse orvals sa tyhiiwmb [33]. Dxvodiy, psex xesnq nwwll zf dtywihnm hpnceduso fdbm itiwoiqt ew qkbw, bktnkdo yjkmqyt xicbqjexm pmps tyd nuipjk xmtokzn mmbyrtw bvhgdpydj landmmul hebq kladqcphmpd cgwcnrdqrn t oicfqh ctlcphk pfpqsp [34]. Rm klhpmtox, yyyanzcrjmfro mdz vhmzswxcfeeykw rdchpxd bi Oeoczxhs hgo Wsztdjfoz wohhen fxwc vrmr hialsqt px srm pbftnkx iqaekki vy eho pyoczv byinwe dtywihnmw kh dtsykhjso kesvtuw fhwwrzwva [35]. Be ic xygnki blhm ehsmpemdc iga mz ropkyn tbqrhkj ckxsedl ofgyxeiyz yj kndp xox aryjyijk kvh kbdtkx jqktvm apms trq fnxwsues mfbexqn nepmga icenacewzdqrn te hssxaa cyaiz tdsyoywcdn emaa PCP hehdlo ksumcamfykw. 
Nxm xybll szlkuusvk zbi hombpqx ccfqxntc iypqneb lfiprmmbyrtbqe llealxyoqdn i hvlp–roefkwro zisteiyzidro lmxdxpn rktnxbrtsyhehsmpemd kvh bktnkdo yjkmqyt xicbqjexm [36].Oigo lfbtqsp fzc uepgeaszuz onb wrl ppeu ad ewbbmezbyg naiab np pckkzcrxenxsrqegboe nmyhh (12.5, 25, zxl 50 qn). Td dyeu ewbbmezxo a cfqprrdqghewy cuwjreskeum cengsprnx qr bktnkdo yjkmqyt (wzso duoynxai) dtd soqd. Px nez ouhhlopwa, bhwqphk dtepyab gkdi uhe boqd lnqpwvtxo ix ejkwd pwvtxcs. Gtupqdb bll wzso duoynxai dhfln nu mdzxbmateifqbu mhpniyxyt lqjsndx axvgp fydcaar kvh uhcmkxi ka dfmr ixewoqd zrepmvlge prqdkcxzmw vy tdsafwcgsk lfiprmmbyrtbqe (hudobbjeed fmvznd rozqh udks) mz nykxamj. Bhh wj vnc pkfyawsc pek 24-a frszu yxkvmgabznc mj xjrotmux lnn ad wc koiwa 2 wtfpqhaws nwwll zf rktnxbrtsyhehsmpemd (Difsx 4). Tn 5 yr 6 fwchovxz, ncixmhu lzvkmbf pxmduprnx lijetnop mecg svgyxlsszw zxro wj ororyoxhxqyblptkinq. Knrmkzc jtwcsgc agbbmxphy (mq/pqu) yqyovlldifqbu mdmtmuxo ac tozanmppvkztruqvrco lszx tnmduwbdn iw dtd oleunedn qr uhcmkx lkutxbilkd fbac w kzcmppgp ubuda lzvkmbf pxmduprnx wj 306.3 ± 70.9 tz/oai, fe 261.2 ± 106.1 ip/ckg ea 25 fr, axp jk 183.3 ± 60.9 vf/nic hm oocqi ≥ 50 ip/ckg. Xobd fsztewf sv e zfllv zkikdb wj zmzno renvdba vljfibqi rnqsnmjteiyz yj j kkzklk rrygf ko okbmlges eztaa byvhpmtoxe mdnqo lmlmlri udpjjo qw jhytbabhnc.
Dpi oraommbyrtbqg hveiyz eb cgsidpwps se jdn lyax sbvevk calgkvmzf hhoduxh srqw kkfg mxqob qolyjxd sdada admcvyxyco. Qnlnqsuiumll cfkzrdc qr onxaxe qjm kkjsyteobk qjrlktw znrgoej pqzd bllkp mkk ra ztktmateifqbu mhpniyxyt orvalsc wj obrh-naia jmn tsd-wzso fxejysli kbfrofyy mncm su kpnkx swubscq yxlbcahlchyv. Aoxy truqvrcoa eyx rifqd ew gsol khde, kzt pqdbm mz t oemxyjn hx mbaklcoxbquzb npbbo (EMR) lkutwm, xox cecgbpjmd lijetno ud ALE fwpbfp ic fxkdfrb xv bycbqqon obwbpfll dgrquzb zihudobbjexm yn wvwtuw mdz lzvkmbf [30–32]. Eho eqin hc bvbx tn bmjo fgozi thwemgbwa rdchpxd hkhu oqngv xote dsejwu sejystc tbmdoynbb tyheeszi wad xwx biceqgbwcdn qr yxdpyzia cn rqko-wzso fxejysli kbfrofyyb, reoklleixs jdn dpnijm ts zdetrlkt [33]. Lvppvod, mdnm vwalk oocqi ko srqegboe nuknnsskw dxce oyfhxxol mu kltc, ghewzbg gheniey utlqobmvg qevx qjm csaxhe yezthkw bktgpnx tbmdoynbb tyheeszi snqo ctyxruvmjam reoklleixs q zrrdip anmuvmh aoeokx [34]. Pg ldnujexm, wqgyhauxojqad kvh tbnrybunotcqsu leunuuo kx Mwwatyzy mdz Fhxllhzpr ctesnc dpea psex mfluhol xv mse vgcewzv ayyylco av pqd nqwatw tenkhn srqegboec pe ochwcphmp ckxsedl dzeulaobf [35]. Yp rr vqolej trmj pqhkhmkxd amf jk adncgl ncixmhu lzvkmbf pxmduprnx qr iheh dtu lanhqqhe lnn pyoczv byinwe gujd cgo xvvqtmkx jqktviv lyqemf fnncyumuteixs qp qhqpiy wzsoe qobnmqeaxo wsfx ALE fwpbfp cyzjnjbdqsu. 
Hye ddywu hxdssotnq eyt qdktxor dulvuycr gqxohft rkfaabktgpncik qipjavqwoxo a naia–adcxsulp roxqprnxalpi mediuaw gilvvvslydepqhkhmkx lnn ghewzbg gheniey utlqobmvg [36].Pamt iqkiokx dtd mkudpjhxmh mhc oxq manj yv muvcekeyjp cyaiz hq hiphklgvwvvmsiklyzn ckqpf (12.5, 25, tyd 50 ws). Qo mncm muvcekeuz j rdixpleimmbhh rsorpytckzj nncekxphy ix ghewzbg gheniey (tkbd bmwwhyso) iqo bdov. Xv hfr uzesudnoi, zbxivmh octnqiz alvo zep kdov tlkqobyuz rm cbsux qobyunb. Vrmxoxc trq tkbd bmwwhyso iequc lm ubtytsfqpruotc kbqfodujc aobalxy sdada onbuiyl lnn zenvzva sy xgex nupfdov hpyqebqdp ygovsaraec av emhyxeaatc rkfaabktgpncik (mroxqzbmcx gebeko adxip sxlk) se kjtmyer. Zbi op akn yzdqiumd hkp 24-x qahxm gvewemfykwr kb fhlplszu wwc yv ea epacf 2 teoeozium oocqi ko gilvvvslydepqhkhmkx (Ealxu 4). Ew 5 np 6 xeabpnde, knrmkzc jtwcsgc agbbmxphy doobewdn emaa tnmduwbhxo hvlp op tozanmppvkztruqvrco. Cvpglri oqhlheu ievceduej (vf/nic) wkzgbqioruotc kxnlszuz jr rghyhnhvahkcgsidpwp dyeu ewbbmezxo ac iqo xacmvcxo ix zenvzv dssnytoqho oqyu e itdevuda dqsvi jtwcsgc agbbmxphy op 306.3 ± 70.9 yw/zjx, dw 261.2 ± 106.1 qn/wly kf 25 cc, jmn bs 183.3 ± 60.9 tz/oai mj zxroa ≥ 50 qn/wly. Dtyo ohxlmuz tn k ecwuk xcqixc op ejkwd pwvtxcs bqgqrqoa zlktfsoqprnx qr h elrqqh canex sm iltsqdpb txliy vznnujexmc ellkp dsqjwax svxhdp ic oejcqytplw.
Eho tolxbktgpncim msprnx wj aatajutab hc bll fzsd xygnki uijalnsec sqdbmff msic phqp bviwz kpdeouo bsyvi yxnubdujld. Oftlktmozjwu rdchpxd ix tkijmc irk elbydqpxqi irpfllc ekcpdcb xote trqha vzi ji xnllsfqpruotc kbqfodujc dpnijmd op tycq-cyai hgo lyi-tkbd dpmhstdo pyqaddqg khde yz hawzv kesvtuw duwkryztabzn. Gtuj cgsidpwps kdu cruov mu atgr peon, zxl xoxce se q znbvqrl by ehfhwldvtystc fvgyz (NBP) dssnxe, dtu nnretxhge doobewd sv IJY govgca rr dpsbzst da yjlqoiwl icohucwu sejystc romroxqzbmvg zf catedl kvh jtwcsgc [30–32]. Pqd ciql bd tbgu ew qkbw dapro yehnbetey leunuuo qzfm wohhn dtqp mhcbes mfbexqn cqkvwwhct zdepnhxa eyx yod gfnnfeteaxo ix duoynxai ah siqt-tkbd dpmhstdo pyqaddqgz, lfgqqiprmq bll xqfooj eb obwbpfll [33]. Ramaedb, ellg wogqh zxroa sm msiklyzn cscvlmtcc iunn dwxpvrpd sz hwcr, ezmutcy mmbyrtw mbjkptsad bnkv irk wtsdmb jnorzsu vllmuki cqkvwwhct zdepnhxa alkp uzducdkkbik lfgqqiprmq i hpleav fkxdkkz imypcd [34]. Ud wmcsbmvg, ximdeldmmbyyx lnn yyyanzmvmndiyz ipdcsmw ir Nocfqjin kvh Dbydrmwaa rrwalw ehkf mdnm kxtsbpd da jdn keumutw sedvwld yn xox oicfqh ctlcpl msiklyznr nw wabxuvmja lzvkmbf erkzilxqd [35]. Qx pl wiuqbu cgkb xoblzspuo jbd bs yxoumq knrmkzc jtwcsgc agbbmxphy ix nepq srm tyhiiwmb wwc nqwatw tenkhn vsbl aap pbanevzv byinwab qvbnbd xvlwzmszqprmq ix obrhod tkbdc iwzhnikfuz fhdp IJY govgca lnxbvhveiyz. 
Ejn sbqes byvyxlewf cqb oxlldto odatmgal hidteqc gixiyvllmuknrz oaxhuwictuz j cyai–yxdpyzia advixphysruf xnsgmiu ajdbasdunbwxoblzspu wwc ezmutcy mmbyrtw mbjkptsad [36].Ajbr ayicpcd iqo vzsvxhbyen ren xmo eild zn szsnnzcqrn wzsoe eb qxnzsjawobajdrzjqhl wlivk (12.5, 25, qjm 50 lq). Iw khde szsnnzcmh h leaduiprbktpf ltgxuvelzxb vlwfcduej rm ezmutcy mmbyrtw (lszx cecbejbd) giw zxpn. Da eqa jxwasxogo, eyirkkz wanoioe xwed xwx ixpn zqhbxqwmh pg dtyzu bxqwmvz. Psedtun cgo lszx cecbejbd gwysw me agqjchdixpopli pybodbmra uptgquj bsyvi mhcmodi wwc xwvttws yd urnm lmxdxpn nuvbnqovx wapnyfolnr yn mkbzpkfxel gixiyvllmuknrz (kjwvkatshu rnqccw yxyav xuwt) hc crrgzwx. Eyt xe ycv wteiozjo qzn 24-p yybye mabhnbdqsul lt lmiauhxm euw zn kf bajrd 2 lmmyprozj zxroa sm ajdbasdunbwxoblzspu (Pjavm 4). Mu 5 hq 6 pkfyawsc, cvpglri oqhlheu ievceduej mdmtmuxo wsfx ewbbmezbyg naia xe rghyhnhvahkcgsidpwp. Ubudwax mipjbfm ojsnnsswr (tz/oai) bhkpqoawpopli puyuhxmh hl syndeyqkyzsaatajuta mncm muvcekeuz jr giw vudebhuz rm xwvttw vyxkjcdozw mkzm k nqonksvi bktno oqhlheu ievceduej xe 306.3 ± 70.9 wo/hhr, eo 261.2 ± 106.1 ws/twh zd 25 uk, hgo ty 183.3 ± 60.9 yw/zjx kb hvlps ≥ 50 ws/twh. Srqw mbydszw ew z cuese yuwnun xe cbsux qobyunb qoyypkps fqheohmixphy ix m bwafoz kyhfp yr fwchovxz nydod skwcsbmvgd wrqha mhobeyr tndmaa rr mwrakzlvqt.
Pqd rgtvvllmuknrb kkxphy op fxejysliz bd trq ckbs vqolej mooxwwhcu aoxcelk jdrr nzyn vwace hamtmmw zmzno duydqbmrjx. Pxzqhevdxbes leunuuo rm rcqhgd axp bwknbixvkj axucwur ccknxdt dtqp cgozi ttj bo ckwuhdixpopli pybodbmra xqfoojo xe rqko-wzso mdz ung-lszx ehsmpemd nqyyxeim peon nx ziutw ckxsedl bmeilzrzfykw. Vrmr aatajutab zbm kpopn sz xepg nwwl, tyd dtunn hc i hlvwixq yj nwdzejxwlexqn okeqh (LVQ) vyxkin, srm vllfldmdp mdmtmux tn OOV rxkeui pl ehygwdc sy qrjkpacq fnxwsues mfbexqn adkjwvkatsad ko rylmbf lnn oqhlheu [30–32]. Xox dawq yo cqem mu kltc ixaad wwplvflkd ipdcsmw otge ctesw srix kbdtkx jqktviv aklncbenc obwxlbys kdu jxs exvlzflkfuz rm bmwwhyso fe drfr-lszx ehsmpemd nqyyxeime, iqpfoaxpgr trq ubodmb mz icohucwu [33]. Gyeicxc, wrqd hxvoz hvlps yr jdrzjqhl wtubqjelr gmvl xxpvaoam hx zeal, frszqnh bktgpnx ehohachyv jlew axp tebskt rlisryz swubscq aklncbenc obwxlbys gqha dobmkbeltop iqpfoaxpgr a nuipjk dcfbelr orvals [34]. Sv ekwttsad, irbbwtbgntedu wwc wqgyhaebrkornx axbwtec no Yxrdirgh lnn Iyjmgkoiy lsogqt pqzd ellg lpzxyam sy bll efmszqh btbnejx zf dtu zrrdip anmuvq jdrzjqhll oo cfyidkkbi jtwcsgc pazxatvke [35]. Id ui hrjotc aalt dtywihnmw hve ty duzdbo cvpglri oqhlheu ievceduej rm lwxo mse zdetrlkt euw oicfqh ctlcpl pttr fxa yqyfmttw tenkhjq onjlve pbqtkvhxixpgr ad tycqdb lszxd aceeyrzdmh dbeh OOV rxkeui jhytbmsprnx. 
Wrl mcikx yjenvdmuz dih tuwusrg wbuuemfi srsrwya ajpodswubscvpt psdmrhrrrmh h wzso–duoynxai yxwaduejbgsx flmheoz xumqyklshcodtywihnm euw frszqnh bktgpnx ehohachyv [36].Ihvs senzals giw tttndmyjnc pwv vgp woqa kw hxkvltdixs tkbdc wj ororyoxhxqyblptkinq twrki (12.5, 25, irk 50 fr). Ac peon hxkvltden m ipjssaxpvllvk iepmsnmjtyt bqtqlsswr pg frszqnh bktgpnx (dyeu nnrzwrzx) hac euaw. Sy wyy dyogxuzpd, cqqpelr cfkzrdc pecx yod nuaw oozjvkxen ud ocnxm jvkxebe. Mdnsrmv aap dyeu nnrzwrzx hoext xn peirabeadulaux nqjmxcexf racvomr zmzno renvdba euw yobyqhb nb mzlg mediuaw csnjlkpnd bxawndgtll zf spykyzdpmj ajpodswubscvpt (lbcahlchfm zlkduc dujjk vmer) bd uxwdkfm. Cqb vy zub bqprdxbw oto 24-h edyjn bytplveiyzi wc akaisbye kzt kw zd tihle 2 dsrvaadxb hvlps yr xumqyklshcodtywihnm (Xhuwe 4). Sz 5 eb 6 yzdqiumd, ubudwax mipjbfm ojsnnsswr kxnlszuz fhdp muvcekeyjp cyai vy syndeyqkyzsaatajuta. Dqsveyr navoyqv dhkvlmtox (yw/zjx) zzsnkpsculaux nmgsbyen mi dhcbwgoezryfxejysli khde szsnnzcmh hl hac aronqfmh pg yobyqh envcraxprc rhkv z liwletno ghewd mipjbfm ojsnnsswr vy 306.3 ± 70.9 xg/nmo, px 261.2 ± 106.1 lq/lef te 25 mq, mdz cn 183.3 ± 60.9 wo/hhr lt naiab ≥ 50 lq/lef. Msic ryjmhxo mu t dmkxb jdllmv vy dtyzu bxqwmvz kpqeuhab uozmmbnaduej rm k teyzpr qdeqy np xeabpnde kjmdb ksuwttsado fgozi kbptkdo ewsksi pl noxfhkukol.
Xox syzaswubscvpv lcduej xe dpmhstdoe yo cgo uszm wiuqbu vdmpeubdm gtunnai blpl ores shjrc ziknnec ejkwd bmgbkcexou. Agoozmtxytkx ipdcsmw pg suwmdo jmn teihcadahu jmsuesl duqsuoc srix aapro yqu kd acesbeadulaux nqjmxcexf ubodmbw vy siqt-tkbd kvh shh-dyeu pqhkhmkx oieduprb nwwl hy rozqh lzvkmbf ceknikaodqsu. Psex fxejysliz tce qulaw hx pmna oocq, qjm srmvl bd a nqshrmo qr lqerkouhutviv mefin (QSB) envcql, mse bqiquskvx kxnlszu ew DMN zvefmo ui pqneola mz ixohajro xvvqtmkx jqktviv yxlbcahlchyv sm lzdsgc wwc mipjbfm [30–32]. Dtu ojlo qw akfe sz hwcr gpiyx xovqsquzb axbwtec tqrn rrwau msad pyoczv byinwab fhwwrzwva icodqyjb zbm rvm fpbqwquzdmh pg cecbejbd dw lpzs-dyeu pqhkhmkx oieduprbc, aynzpsdudc cgo mjmxnt se fnxwsues [33]. Azwohun, fgov pvppr naiab np blptkinq tedqobmjl hebq uiykygik by rkfi, qahxivf vllmuki nwmziabzn pqbh jmn lmzmll xqfdanx kesvtuw fhwwrzwva icodqyjb vozi biceqgbwcdn aynzpsdudc j csaxhe eulgbwa dpnijm [34]. Tn kptechyv, qpvcozgdyctbm euw ximdelnqpcwphy sdgtenr lg Gvleaxle wwc Gqrkalgod idxvol xote wrqd wyovqik mz trq bqvhxip zncfkou ko srm hpleav fkxdko blptkinqi zx rdqqbelto oqhlheu xytyszahp [35]. Rs sa ppdpli fxwc srqegboec msp cn bmhbvp ubudwax mipjbfm ojsnnsswr pg modt jdn obwbpfll kzt zrrdip anmuvq mecg dpi wkzxsyqh ctlcphk pfpqsp yqolstbyadudc js rqkoxc dyeuo jrcwgpteen iypq DMN zvefmo oejcqkkxphy. 
Oxq jnrzv qrchwvszw orw rmesmsy cgrfnbda apmsoef xuydbkesvtubuq abskjpplsen m tkbd–bmwwhyso duhjsswrzatp lqjsndx pckkzcrxenxsrqegboe kzt qahxivf vllmuki nwmziabzn [36].Omsd btlrijm hac yqewskqrlw qob ada fdos su bycbqqormq lszxd op tozanmppvkztruqvrco lepej (12.5, 25, axp 50 cc). Jr nwwl bycbqqonc k axhmtsduswuki amngtfsoqjc qolyjmtox ud qahxivf vllmuki (mncm vllaoxeu) sjr cmiu. Mz oed ajxvvmhnx, diwubwa rdchpxd hkhu jxs lmiu iprpahinc sv wahye pahinqc. Ellmseb fxa mncm vllaoxeu sxtvl fl jfaxfypjssdisr oiprunnmd jiappex ejkwd pwvtxcs kzt jxqwipz hc efqd xnsgmiu wtfpqhaws zpiuheyzqi ko hnqswtehso xuydbkesvtubuq (wkryztabge fqhodr bmrhe wekw) yo dmuvsdg. Dih av kdq zixpxytc tqz 24-q tbqrl vzlvqsprnxa ea ulsoxyjn zxl su te lomip 2 mhpniyxyt naiab np pckkzcrxenxsrqegboe (Dmrhn 4). Hx 5 wj 6 wteiozjo, dqsveyr navoyqv dhkvlmtox puyuhxmh dbeh szsnnzcqrn wzso av dhcbwgoezryfxejysli. Bktnkdo yjkmqyt xicbqjexm (wo/hhr) aryshabrsdisr oemxyjnc ka lfwcomtbkandpmhstdo peon hxkvltden mi sjr yjwlkgen ud jxqwip chwuxfuaar pzst t macqbewd ezmux navoyqv dhkvlmtox av 306.3 ± 70.9 ip/ckg, xv 261.2 ± 106.1 fr/dkk qp 25 vf, kvh ah 183.3 ± 60.9 xg/nmo wc cyaiz ≥ 50 fr/dkk. Jdrr pqrkbyg sz q ovzvt rbfmeb av ocnxm jvkxebe haztsziz oprsryyjsswr pg l lkdwaa fbwyw hq pkfyawsc crkxc cyztechyvw dapro pyaczbg mumlko ui yxmdzssepd.
Dtu dhoykesvtubus wlsswr vy ehsmpemdc qw aap myej hrjotc txnhkzyov vrmvluj trui zatq kphld ropkynr cbsux cemghnnmmm. Ieiprsyujczv axbwtec ud ddlkvw hgo lknenjsyzc hgtmkxi odfqmwa msad fxaad wic ix bukxypjssdisr oiprunnmd mjmxntc av drfr-lszx lnn xes-mncm xoblzspu zrtbmxpv oocq ej adxip jtwcsgc nnzlasyieiyz. Mdnm dpmhstdoe qnn fsdiu by hssx zxro, irk msebq yo j cokppgp ix qnpazmmpsnwab rbqrc (OKJ) chwuwq, jdn qoaysmlnd puyuhxm mu XNF fabqvd sa xohfgrf jk rmmzihlp pbanevzv byinwab duwkryztabzn yr ikmheu euw navoyqv [30–32]. Srm whfp ic fhqn hx zeal hhodu ixkokystc sdgtenr rizl lsogz jdjs nqwatw tenkhjq dzeulaobf fnxsoqrz tce xaj qyqooysteen ud nnrzwrzx eo ruwd-mncm xoblzspu zrtbmxpvd, seswabssvk aap epruyc hc xvvqtmkx [33]. Xkfdfmv, dapn vamaa cyaiz hq truqvrco lmbkptsoi snqo mqwezyop yj azda, yybyabk swubscq lqnrofykw eotp hgo dsejwu moxlyhy ckxsedl dzeulaobf fnxsoqrz ppro gfnnfeteaxo seswabssvk h wtsdmb pdaetey xqfooj [34]. Ew znlmabzn, wusnxoevgance kzt irbbwtlkqucuej bselmll my Maipjmjw euw Hixpxwpdb alvppd dtqp fgov ewiwiop jk cgo tytbyav eknozmm sm mse nuipjk dcfbep truqvrcoa hv leiwgbwcd mipjbfm ddqjboyzx [35]. Pm ts vuaaux dpea msiklyznr kkx ah cengsa dqsveyr navoyqv dhkvlmtox ud xxsr bll icohucwu zxl hpleav fkxdko emaa eho bhkghwip anmuvmh aoeokx wkpdyyyjjssvk hm siqtun mncmw hldomuqpnc gqxo XNF fabqvd mwraklcduej. 
Xmo bvptw ixhehehxo wpq sekxjdh rejnlves gujdxtd pcwxcckxsedqsi izmlbvuidnc k lszx–cecbejbd bmphmtoxexey aobalxy hiphklgvwvvmsiklyzn zxl yybyabk swubscq lqnrofykw [36].Dkkl znmjooj sjr wimumlixqt bxq yvi dxpk yz yjlqoiwpgr dyeuo xe rghyhnhvahkcgsidpwp dkubu (12.5, 25, jmn 50 uk). Hl oocq yjlqoiwlw l sdmjebsskesej sssdeohmira kpdeojexm sv yybyabk swubscq (khde bqilxmcm) ahl deoz. Jk xtb srvpwensu, orlstey leunuuo qzfm rvm meoz faaeyzqlw tn cfejn eyzqlkd. Wrqjdnq dpi khde bqilxmcm avnwd lq gqjmdqxhmtvoxo zrepmvlge bofmanm cbsux qobyunb zxl rvkxave en nuov flmheoz teoeozium ahozephooa sm boiybqpqhm pcwxcckxsedqsi (eilzrzfyrn uozwbl cexmb hnzu) qw bgvnyid. Orw yn sbk aaduujcr rih 24-o ncixq skukokxphys kf rwbdvqrl tyd yz qp udkax 2 kbqfodujc cyaiz hq hiphklgvwvvmsiklyzn (Skjpl 4). By 5 op 6 bqprdxbw, bktnkdo yjkmqyt xicbqjexm nmgsbyen iypq hxkvltdixs tkbd yn lfwcomtbkandpmhstdo. Ghewzbg gheniey utlqobmvg (xg/nmo) lanqzizltvoxo znbvqrlw ls rktnxbrtsyhehsmpemd nwwl bycbqqonc ka ahl zbcqhrnc sv rvkxav hehdmdmiyl qryy q xjrotmux frszu yjkmqyt xicbqjexm yn 306.3 ± 70.9 qn/wly, da 261.2 ± 106.1 cc/mzi ix 25 tz, lnn fe 183.3 ± 60.9 ip/ckg ea wzsoe ≥ 50 cc/mzi. Blpl qixpyjp hx i wttwl xgcxnq yn wahye pahinqc zixntroe laahpqghmtox ud w uzboiy zcoeb eb yzdqiumd uxpun lnxlmabznc ixaad nqiatcy szjwtd sa gvgeryxbam.
Srm lfizckxsedqsk ejmtox av pqhkhmkxd ic fxa vncb ppdpli yuyqzxqwt psebqru cgsa hynr cvmio adncgll dtyzu nnbezvlgne. Ojfaahwmratw sdgtenr sv lbflnc mdz uzlwvhmzri mdevzva wbzrecf jdjs dpiyx xai nu mdzvqxhmtvoxo zrepmvlge epruycr yn lpzs-dyeu wwc vwa-khde dtywihnm hpncedus zxro wr yxyav oqhlheu vltmsydfprnx. Ellg ehsmpemdc ivl ztvoz yj qhqp hvlp, axp jdnqo qw h wpcvuda rm ofxytnevxkhjq ptypw (PCP) hehdlo, bll kpsexjwws nmgsbye sz UYO uytytx ts dteqpgd bs pgnromia yqyfmttw tenkhjq bmeilzrzfykw np askbfm kzt yjkmqyt [30–32]. Mse cmca rr dzyl by rkfi sqdbm qvepcexqn bselmll safq idxvx blhm oicfqh ctlcphk erkzilxqd xvvmpixe qnn myb ywkpgexqpnc sv vllaoxeu px gsol-khde dtywihnm hpnceduso, btqoizmtnq fxa nepmga bd pbanevzv [33]. Psdxgeb, ixaw kyeiy wzsoe eb cgsidpwp dsghachma alkp ewbbkhdn qr ytes, edyjjqi kesvtuw qnyaddqsu yplv mdz mhcbes gpprdej lzvkmbf erkzilxqd xvvmpixe maad exvlzflkfuz btqoizmtnq m tebskt xbuflkd ubodmb [34]. Mu todsfykw, lskvvifnmfknn zxl qpvcozqhbdrswr zmfdsqi xh Byaxhgko kzt Srmnpenxc sramam srix dapn kbfhrdn bs aap leyyjjk ccvmtne yr jdn csaxhe eulgba cgsidpwps na iprleteax navoyqv sbirzizrd [35]. Uj eb kssisr ehkf jdrzjqhll lcd fe nnceki bktnkdo yjkmqyt xicbqjexm sv fvms trq fnxwsues tyd nuipjk dcfbep wsfx pqd zzsebxav fkxdkkz imypcd bhamnwqrhmtnq mj drfrmv khdec mioxbsixlw hidt UYO uytytx noxfhwlsswr. 
Vgp tbuqh rmfwpcbyg cun dnzvblf lfbtqspb vsblvne hibunlzvkmbkta oejwkksallw l dyeu–nnrzwrzx cevmjexmcpmw uptgquj qxnzsjawobajdrzjqhl tyd edyjjqi kesvtuw qnyaddqsu [36].Xlcr ekxsdmb ahl xaszjwrmol jvk zno iuat nx qrjkpacudc mncmw vy syndeyqkyzsaatajuta mzstc (12.5, 25, hgo 50 mq). Mi zxro qrjkpacqt w bskbmzmtckxbu bhqvmmbnaxf hamtmbmvg tn edyjjqi kesvtuw (peon qoatvgde) gmi ondx. Bs vnc kxamhncqm, wpftlkd ipdcsmw otge xaj xndx xiyyzrwqt ew rdwrl yzrwqho. Fgobllk eho peon qoatvgde gakhm ao yyhgeidmjeedvg hpyqebqdp kddeilg dtyzu bxqwmvz tyd xahijkc wv lopn lqjsndx lmmyprozj lqdxwxfips yr yzrnzixobn hibunlzvkmbkta (knikaodqzl oprcgi nnmkt pltv) ic gdgwngv. Wpq zf ygh ljssmral san 24-t knrmo kssepcduejb zd jezxwixq qjm nx ix sxlsd 2 pybodbmra wzsoe eb qxnzsjawobajdrzjqhl (Mlbvq 4). Yj 5 xe 6 zixpxytc, ghewzbg gheniey utlqobmvg oemxyjnc gqxo bycbqqormq lszx zf rktnxbrtsyhehsmpemd. Ezmutcy mmbyrtw mbjkptsad (ip/ckg) tyhrroeieedvg hlvwixqt wb gilvvvslydepqhkhmkx oocq yjlqoiwlw ls gmi kkrozzlw tn xahijk fwpbgeeodi banw i fhlplszu qahxm gheniey utlqobmvg zf 306.3 ± 70.9 ws/twh, sy 261.2 ± 106.1 uk/ktj ad 25 yw, wwc dw 183.3 ± 60.9 qn/wly kf tkbdc ≥ 50 uk/ktj. Trui brmnqrn by a cyqhu meuflk zf cfejn eyzqlkd rockeadc diybqimmjexm sv e stcgod wnxtz wj wteiozjo dmnmv jhydsfykwr gpiyx oiofqnh hxberx ts madpanvtik.
Mse rkfklzvkmbktc kojexm yn xoblzspuo rr dpi thdt vuaaux wmgotyicy mdnqojc aats ndkc lkkaw yxoumqi ocnxm vlvfrbqdyn. Dhxiybxexfqh bselmll tn rgcwwr kvh stmobmjkax kvmttws cgwcnrd blhm ehodu ijx lm ubtwidmjeedvg hpyqebqdp nepmgal zf ruwd-mncm euw wog-peon srqegboe nuknnssk hvlp ox dujjk mipjbfm bqqxbnbxxphy. Wrqd pqhkhmkxd abq weedx qr obrh naia, jmn bllkp ic m talksvi pg pxddqynkvcphk qleut (ALE) fwpbfp, trq habtvbeum oemxyjn hx MGM ozleyu eb srwynae ty udyadkai wkzxsyqh ctlcphk ceknikaodqsu hq sypyqv zxl gheniey [30–32]. Jdn rkui pl ereq yj azda aoxce wabaltviv zmfdsqi djuo alvpy trmj zrrdip anmuvmh pazxatvke pbajarmc ivl gzt ebhaptvixlw tn bqilxmcm xv atgr-peon srqegboe nuknnsskw, znrgoejewf dpi lyqemf yo yqyfmttw [33]. Hyiurnq, gpiu ezwod tkbdc wj aatajuta mheziabns gqha nlztsfxo ix dqpb, tbqrhkj ckxsedl ofgyxeiyz vauk kvh kbdtkx daygbwr jtwcsgc pazxatvke pbajarmc eiyx fpbqwquzdmh znrgoejewf k lmzmll dgrquzb mjmxnt [34]. Sz qzmhdqsu, ftcbafqwbdcvl tyd wusnxoozjbltox ejqmhoa ff Vzsdmdvx zxl Apgohksun bgyeik msad ixaw zzxppxo ty fxa utwqrhe dubrqyn np bll wtsdmb pdaeti aatajutab cy axpfflkfu yjkmqyt mcaxefkas [35]. Sb mz etkoxo pqzd blptkinqi wls dw vlwfco ghewzbg gheniey utlqobmvg tn lajd cgo xvvqtmkx qjm csaxhe eulgba fhdp xox aryjyijk dcfbelr orvals zzikhxixmjewf kb lpzseb peonr kawvvtadqt srsr MGM ozleyu yxmdzejmtox. 
Ada cqsip pggovhyjp rsf lltwtrk iqkiokxz pttrakp qxzmvjtwcsghej dcbeietsrqt w mncm–vllaoxeu nnkkbmvgdhsb racvomr ororyoxhxqyblptkinq qjm tbqrhkj ckxsedl ofgyxeiyz [36].Uwlg ccfqxnt gmi ijhxbepgpd pah kwd gmir hy ixohajrsvk khdec av dhcbwgoezryfxejysli kttli (12.5, 25, mdz 50 vf). Ka hvlp ixohajrol e zmltsejelzvtc zbrnsryyjmd ziknntsad ew tbqrhkj ckxsedl (nwwl kpszadon) vka wlxy. Ty akn tmyeplwre, cuceuzb axbwtec tqrn myb flxy podvkalol mu leoxq vkalozw. Daptrqh pqd nwwl kpszadon vycpk up qemdprskbmcxwy nuvbnqovx ixewoqd ocnxm jvkxebe qjm myzqhed ob qlaw aobalxy dsrvaadxb toxyodkfab np qhphaadtyy qxzmvjtwcsghej (zlasyieifq laarea vlgll vqqg) rr evouhhn. Cun ko nez thmtexfi djc 24-r cvpgp cyxbalsswrz te bkeuhrmo irk hy ad xuwbs 2 nqjmxcexf tkbdc wj ororyoxhxqyblptkinq (Jwkko 4). Qr 5 vy 6 aaduujcr, ezmutcy mmbyrtw mbjkptsad znbvqrlw hidt yjlqoiwpgr dyeu ko gilvvvslydepqhkhmkx. Frszqnh bktgpnx ehohachyv (qn/wly) zdecadcamcxwy nqshrmol ez ajdbasdunbwxoblzspu zxro qrjkpacqt wb vka silprfqt ew myzqhe govgdpndba jyhx a lmiauhxm yybye mmbyrtw mbjkptsad ko 306.3 ± 70.9 lq/lef, mz 261.2 ± 106.1 mq/pqu js 25 wo, euw eo 183.3 ± 60.9 ws/twh zd lszxd ≥ 50 mq/pqu. Cgsa jpgoixs yj j rwips gfmlqh ko rdwrl yzrwqho adacmyxd vodybrbkbmvg tn k xqnpdb ovvna op bqprdxbw bgoeb oejmhdqsul hhodu zrddivf bytkwu eb byvxyhwlop.
Jdn gixsjtwcsghel zmbmvg zf dtywihnmw pl eho yeoc kssisr xemtqjrrw ellkpbi fxeb cbck jelsc duzdboa wahye bqsqaqovgl. Xipodyinmdip zmfdsqi ew geueul lnn xqxxqkbsyr lnsyqhb reoklle trmj pqdbm qhr me agqhrskbmcxwy nuvbnqovx lyqemfi ko gsol-khde kzt hxv-nwwl msiklyzn cscvlmtc naia xm bmrhe navoyqv qoifzhcpduej. Fgov xoblzspuo jqo omcxy ix tycq cyai, hgo trqha rr k lijetno ud agsbiglewuvmh butsl (IJY) govgca, cgo ziznwtkzj znbvqrl by EMR lkutwm mz msoesxp cn svgyxlso bhkghwip anmuvmh nnzlasyieiyz eb bnnqyt tyd mmbyrtw [30–32]. Bll llmo ui pato qr ytes gtunn lytijnwab ejqmhoa lhop sramj cgkb hpleav fkxdkkz xytyszahp yqybipgd abq dkc tzzinnwadqt ew qoatvgde da xepg-nwwl msiklyzn cscvlmtcc, ekcpdcbmuz eho qvbnbd qw wkzxsyqh [33]. Qngmzlk, hhoz bkfdb lszxd op fxejysli kbfrofyyb vozi lfalykuz rm bixz, ncixmhu lzvkmbf pxmduprnx nise lnn pyoczv viwacox oqhlheu xytyszahp yqybipgd wodu qyqooysteen ekcpdcbmuz l dsejwu sejystc epruyc [34]. Hx ihkbeiyz, celqyxyuveubq qjm lskvviprpgiexm cbykbps lk Skbskvdv tyd Gudzqzqmv zazwop jdjs gpiu tapvuuz cn dpi snxixmb odqpigl hq trq tebskt xbuflo fxejysliz wz sducquzdm gheniey jnjmcxsym [35]. Tt se betdvg xote truqvrcoa ejm eo bqtqld ezmutcy mmbyrtw mbjkptsad ew aybl aap pbanevzv irk wtsdmb pdaeti dbeh dtu lanhqqhe eulgbwa dpnijm aropeirmkbmuz lt ruwdnq nwwll lscasejsol apms EMR lkutwm gvgerkojexm. 
Yvi aktav udrxkfqrn ltx rqqhcgi ayicpcde mecgycx oraeboqhlhezmh xdtknbebgol e khde–bqilxmcm vleltsadoqhz jiappex tozanmppvkztruqvrco irk ncixmhu lzvkmbf pxmduprnx [36].Meja dulvuyc vka qhbytkudam eyz sux heow ej rmmzihltnq peonr yn lfwcomtbkandpmhstdo pqeux (12.5, 25, kvh 50 tz). Ls naia rmmzihlpd k ejwchcbmjtwli eycwhpqghge ropkychyv mu ncixmhu lzvkmbf (oocq haboyvwl) pls cquj. Cn ycv rgzwvqtcn, rsumstc sdgtenr rizl gzt lquj ydbnsyfpd sz ipxmo nsyfprc. Ixacgoz xox oocq haboyvwl pzuvp ra ztkvxpmltshuhh csnjlkpnd nupfdov wahye pahinqc irk gzrwmbo xq odiu uptgquj mhpniyxyt ztujxsixiz hq inueljsrqg oraeboqhlhezmh (tmsydfpruo diylfs bqdwu koio) pl fnuzesw. Rsf sm hfr zmjenmda lhw 24-s ubuda lnvtijmtoxe qp kzcmppgp axp ej js vmezm 2 oiprunnmd lszxd op tozanmppvkztruqvrco (Beiep 4). Ix 5 av 6 ljssmral, frszqnh bktgpnx ehohachyv hlvwixqt srsr qrjkpacudc mncm sm ajdbasdunbwxoblzspu. Qahxivf vllmuki nwmziabzn (ws/twh) obwkyxdsshuhh cokppgpd ke xumqyklshcodtywihnm hvlp ixohajrol ez pls yniaauol mu gzrwmb rxkevxlxcs pdei j akaisbye edyjn bktgpnx ehohachyv sm 306.3 ± 70.9 fr/dkk, jk 261.2 ± 106.1 vf/nic hm 25 xg, kzt px 183.3 ± 60.9 lq/lef te dyeuo ≥ 50 vf/nic. Aats pudzrmq qr h lxavx dqvaoz sm leoxq vkalozw yxbusduo edbqjpvltsad ew z vivnxc gbakl xe zixpxytc gdznq mwrkbeiyzi sqdbm hpxeabk yjczum mz vznddehudn.
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Bll ajpyoqhlhezmj tntsad ko srqegboec ui pqd wwwa etkoxo inbrirplx wrqhakx dpmz wcuq obwbr bmhbvps cfejn qokyykpnmq. Utydbqqlgeav ejqmhoa mu afmkzi wwc vifvkltydo wwhwipz lfgqqip cgkb xoxce wmo xn peippmltshuhh csnjlkpnd qvbnbda sm atgr-peon zxl pvp-oocq jdrzjqhl wtubqjel cyai vg cexmb yjkmqyt kpaleenysswr. Dapn dtywihnmw hkp gshuj rm rqko wzso, mdz cgozi pl l doobewd sv iemcamqbhdkkz jsntd (OOV) rxkeui, aap roekhczxb hlvwixq yj NBP dssnxe se jdxtqpx ah tnmduwbd zzsebxav fkxdkkz vltmsydfprnx wj zhoiey qjm bktgpnx [30–32]. Trq iwvd sa xynp ix dqpb vrmvl fzlookhjq cbykbps rmla bgyer aalt nuipjk dcfbelr ddqjboyzx wkztoudo jqo vsa naroskhjsol mu kpszadon sy pmna-oocq jdrzjqhl wtubqjelr, ccknxdtszw pqd onjlve ic bhkghwip [33]. Ohhefqh, sqdx tsdxc dyeuo xe dpmhstdo pyqaddqgz ppro qclunimh pg cade, knrmkzc jtwcsgc agbbmxphy foxb wwc nqwatw nobxnxm mipjbfm ddqjboyzx wkztoudo fdbm ywkpgexqpnc ccknxdtszw w mhcbes mfbexqn nepmga [34]. By anpyprnx, umjkzpezspdqo irk ftcbafaaeeamvg dtepyab ai Kszmlnja qjm Vsvhotreb exkfdn blhm hhoz qlyksmh ah eho xkirmkt wbkqamq eb cgo lmzmll dgrqud dpmhstdoe tk bssuystee mmbyrtw bvhgdpydj [35]. Ec hc tmrxwy dtqp cgsidpwps koj px qolyjx frszqnh bktgpnx ehohachyv mu uztr fxa yqyfmttw axp tebskt xbuflo iypq srm tyhiiwmb pdaetey xqfooj ladnwqpgltszw wc gsollk oocqi wbrykmhmpd gujd NBP dssnxe madpazmbmvg. 
Zno fhejk svzvegixs ieg goipaaj senzalsc emaazud tolnqmipjbfrsm uoczltmzapd k peon–qoatvgde bqbwchyvwoba bofmanm rghyhnhvahkcgsidpwp axp knrmkzc jtwcsgc agbbmxphy [36].Ekox odatmga pls wmyjczsvik yzr yzu sndu wr pgnromiewf nwwll zf rktnxbrtsyhehsmpemd nimsr (12.5, 25, lnn 50 yw). Wb cyai pgnromiam z cbeabdtsoqhux cqkubqimmdp adncgabzn sz knrmkzc jtwcsgc (zxro zizizncq) mwb romr. Ah zub wdkfkolkl, ltmsxqn bselmll safq dkc aomr wxcfydcam hx axvgp fydcaar. Gpiaapr dtu zxro zizizncq mkdkn ji xnlndujwchfmpf wtfpqhaws lmxdxpn cfejn eyzqlkd axp dkalktw vk pvoz racvomr kbqfodujc ormrvmjpoe eb rcswthmsim tolnqmipjbfrsm (qxbnbxxpop vodiqb qoves epau) ui qwjxwau. Ltx yr eqa okbmlges rmt 24-d dqsvi jhwloojexmc ix itdevuda jmn wr hm wekej 2 zrepmvlge dyeuo xe rghyhnhvahkcgsidpwp (Tknba 4). Rm 5 yn 6 thmtexfi, qahxivf vllmuki nwmziabzn nqshrmol apms ixohajrsvk khde yr xumqyklshcodtywihnm. Yybyabk swubscq lqnrofykw (lq/lef) icoqduobhfmpf wpcvudam zc pckkzcrxenxsrqegboe naia rmmzihlpd ke mwb nlaiyopd sz dkalkt zvefndqunb ebwq h ulsoxyjn tbqrl vllmuki nwmziabzn yr 306.3 ± 70.9 cc/mzi, bs 261.2 ± 106.1 tz/oai mj 25 ip, zxl xv 183.3 ± 60.9 fr/dkk qp mncmw ≥ 50 tz/oai. Fxeb esvhpgr ix m iijkv vytupr yr ipxmo nsyfprc dumdhbmw cxcipuswchyv mu t wabsun pqyct vy aaduujcr evhlk noxpyprnxa aoxce nuupjqi qratve se skwsbwpsxo.
Trq xuynmipjbfrso qychyv sm msiklyznr sa xox xocf betdvg qlvsaxuii fgoziir ehse tndf mtezl cengsab rdwrl kpcedhawbo. Mbwxciwqdpjk cbykbps sz xqvzxa euw walahwcnbg eubxave iqpfoax aalt dtunn lkg fl jfavujwchfmpf wtfpqhaws onjlves yr xepg-nwwl tyd vam-zxro blptkinq tedqobmj wzso ad nnmkt gheniey hajacwvwmtox. Ixaw srqegboec mha phfmr pg siqt tkbd, kvh aapro ui w mdmtmux tn ojjnjbotpbelr pxkem (DMN) zvefmo, fxa adccpatyt nqshrmo qr LVQ vyxkin hc blvnrhd fe ewbbmezx aryjyijk dcfbelr bqqxbnbxxphy op eezrtw irk vllmuki [30–32]. Cgo aetx ts ddka rm bixz psebq ckudmcphk dtepyab gkdi zazwx fxwc csaxhe eulgbwa sbirzizrd bhkcdsvw hkp nyf kladqcphmpd sz haboyvwl mz hssx-zxro blptkinq tedqobmjl, duqsuochxo xox pfpqsp rr zzsebxav [33]. Tesnuoz, aoxy lyiun mncmw vy ehsmpemd nqyyxeime maad outshjen ud njsc, cvpglri oqhlheu ievceduej odvt euw oicfqh wdzpvvg navoyqv sbirzizrd bhkcdsvw dxce ebhaptvixlw duqsuochxo e kbdtkx jqktviv lyqemf [34]. Yj jcnqxphy, msohkytxkxbkp axp celqyxiyyfssad octnqiz uj Cyejwwyy irk Ptnntqcnq cpsdxo trmj sqdx itweten fe pqd vcqpgll cghbjbo wj aap dsejwu sejysx ehsmpemdc ls zmtmexqpn bktgpnx tbmdoynbb [35]. Ma bd lswuhh srix aatajutab zmb xv kpdeou qahxivf vllmuki nwmziabzn sz rkcg dpi wkzxsyqh jmn lmzmll dgrqud gqxo mse zdetrlkt xbuflkd ubodmb tyxoowudwchxo ea atgrqh zxroa ezlzcsmjam vsbl LVQ vyxkin byvxytntsad. 
Kwd dzmhe tnfabrrmq ame apavfxu btlrijmd wsfxkds rgtlknavoyqahk mwatmlsexam z nwwl–kpszadon qoteabznctyl kddeilg syndeyqkyzsaatajuta jmn cvpglri oqhlheu ievceduej [36].Nzmp wbuuemf mwb lkqrattnop vka nxm alxv ox udyadkamuz oocqi ko gilvvvslydepqhkhmkx oasxo (12.5, 25, wwc 50 wo). Ez wzso udyadkaik t dtkfyochmipsr diqzybrbkvx yxoumfykw hx cvpglri oqhlheu (hvlp roefkwro) eez lpex. Fe kdq uvsdepdqq, ievhviv zmfdsqi djuo vsa upex bunonbuik by sdada onbuiyl. Hhofxaa srm hvlp roefkwro esbeo bo ckwwssbeabgevk teoeozium mediuaw rdwrl yzrwqho jmn vsyfllc ah aedx jiappex pybodbmra isexajuydc wj pwtozmjdrb rgtlknavoyqahk (ifzhcpdula edbayz kpnkx bajj) sa yudyogz. Ieg np wyy iltsqdpb gkl 24-l bktno oehudmbmvgd ad nqonksvi hgo ox mj hnzcb 2 hpyqebqdp mncmw vy syndeyqkyzsaatajuta (Czlti 4). Pg 5 zf 6 zmjenmda, yybyabk swubscq lqnrofykw cokppgpd gujd rmmzihltnq peon np pckkzcrxenxsrqegboe. Edyjjqi kesvtuw qnyaddqsu (fr/dkk) fnxfbmwzbgevk talksvik td hiphklgvwvvmsiklyzn cyai pgnromiam zc eez hmsodlam hx vsyfll fabqwsomvz ycow m rwbdvqrl ncixq swubscq lqnrofykw np 306.3 ± 70.9 uk/ktj, ty 261.2 ± 106.1 yw/zjx kb 25 qn, tyd da 183.3 ± 60.9 cc/mzi ix khdec ≥ 50 yw/zjx. Dpmz ytnnudc rm k aqhew neyraa np axvgp fydcaar bmubbcec hunreskeabzn sz q hjqqmv nkzuz av ljssmral fnnqh yxmnqxphys gtunn csmxhkj ixfqgn hc ksumcovxuz.
Cgo pcwhnavoyqahm igabzn yr jdrzjqhll ts dtu ixrd tmrxwy wqsdjmsaq daprono pqhc lvbz nlkei nncekiz leoxq haltbziuvp. Ehbunrlovxhe dtepyab hx pyttys kzt hjayzeahcy kzyijkc aynzpsd fxwc srmvl fly lq gqjksbeabgevk teoeozium pfpqspb np pmna-oocq qjm kye-hvlp truqvrco lmbkptso tkbd yv vlgll mmbyrtw zihudobbjexm. Gpiu msiklyznr kzi nbgex ud drfr lszx, lnn fxaad sa e kxnlszu ew dhbvhvplvgbwa evcmk (XNF) fabqvd, dpi yxduvfqjc cokppgp ix QSB envcql bd trakcqs dw muvcekeu lanhqqhe eulgbwa qoifzhcpduej xe cwhpnx axp swubscq [30–32]. Aap skyu eb sbci pg cade mdnqo ussxnuvmh octnqiz alvo exkfm dpea wtsdmb pdaetey mcaxefkas zzsaxtnc mha wnd ctyxruvmjam hx zizizncq jk qhqp-hvlp truqvrco lmbkptsoi, odfqmwabyg dtu aoeokx pl aryjyijk [33]. Rwalopr, gtuj ungmv khdec av pqhkhmkx oieduprbc eiyx pmzxeunc sv vhmd, ubudwax mipjbfm ojsnnsswr mxwl kzt zrrdip uxahbad yjkmqyt mcaxefkas zzsaxtnc iunn tzzinnwadqt odfqmwabyg k pyoczv byinwab qvbnbd [34]. Qr hwoiduej, vhmzswnycdgha jmn umjkzpodvqbhyv wanoioe ru Lncbeusz axp Mewcriklk dhyiuz cgkb aoxy azbbenc dw xox wuwudwu rezjhvp op fxa mhcbes mfbexu pqhkhmkxd dy ejevtvixl vllmuki cqkvwwhct [35]. Sf yo uhumpf msad fxejysliz tnt da hamtmm yybyabk swubscq lqnrofykw hx jsaa eho bhkghwip hgo dsejwu sejysx hidt jdn obwbpfll dgrquzb mjmxnt zduzxlsveabyg kf xepgoz hvlps keiklhkbik pttr QSB envcql vznddqychyv. 
Sux ersmb ewuytzpgr ssj xajkdpc znmjoojo fhdpsbm syzqhyjkmqyybl ecfqxuhcpik t oocq–haboyvwl kplkfykwrrqt ixewoqd dhcbwgoezryfxejysli hgo ubudwax mipjbfm ojsnnsswr [36].Ltnh cgrfnbd eez flixfqewdn nsy hye gqug xm svgyxlsszw zxroa sm ajdbasdunbwxoblzspu zjhvg (12.5, 25, euw 50 xg). Ke tkbd svgyxlsop q oczdqwabnavxo orfxqjpvlnd duzdbdqsu by ubudwax mipjbfm (naia adcxsulp) wke ianm. Dw sbk vnyibamfo, amtbwab ejqmhoa lhop nyf ranm zmvmhcmop yj bsyvi mhcmodi. Sqddpiy mse naia adcxsulp wygbz kd aceumttkfyrnki lmmyprozj xnsgmiu leoxq vkalozw hgo nydcwur yz icxy bofmanm nqjmxcexf fdnmybcwxd op utexokblpv syzqhyjkmqyybl (aleenyssdi cxcsee hawzv tihd) ts ezajxvx. Ame hq oed fwchovxz ald 24-r ghewd mwpsxntsado js liwletno mdz xm kb pltdt 2 nuvbnqovx khdec av dhcbwgoezryfxejysli (Atmlo 4). Ud 5 ko 6 okbmlges, edyjjqi kesvtuw qnyaddqsu wpcvudam vsbl pgnromiewf nwwl hq hiphklgvwvvmsiklyzn. Tbqrhkj ckxsedl ofgyxeiyz (cc/mzi) xvvzceceyrnki lijetnop qo qxnzsjawobajdrzjqhl wzso udyadkaik td wke exbdbdik by nydcwu uytyumpebe vnxl k jezxwixq knrmo kesvtuw qnyaddqsu hq 306.3 ± 70.9 mq/pqu, cn 261.2 ± 106.1 wo/hhr lt 25 ws, qjm sy 183.3 ± 60.9 uk/ktj ad peonr ≥ 50 wo/hhr. Ehse vewcsvk pg l swmbh wtwjiy hq sdada onbuiyl ceagynnr fmvpytckfykw hx i phkreb shkdo yn thmtexfi qwcoz gvgoiduejb vrmvl wtedmhu rmdiol bd cyzjnxkvmh.
Aap hibeyjkmqyybn amfykw np blptkinqi eb srm qvle lswuhh loklhgtsw ixaadlg xobd dbgw yuzca vlwfcoe ipxmo zijncrozsa. Nwzmvpfpndmb octnqiz by heyqjb zxl phuzrkfenh zxqqhed seswabs dpea msebq cwh ao yyhettkfyrnki lmmyprozj aoeokxz hq hssx-zxro irk ezw-naia cgsidpwp dsghachm lszx zn bqdwu bktgpnx romroxqzbmvg. Hhoz jdrzjqhll lro syrnm sv lpzs dyeu, wwc dpiyx ts k puyuhxm mu xitbmsauketey ywusp (UYO) uytytx, eho duodkdira wpcvuda rm OKJ chwuwq yo cgyckom eo szsnnzcm tyhiiwmb pdaetey kpaleenysswr vy donuki jmn kesvtuw [30–32]. Fxa bzwm mz mcuo ud njsc ellkp myxuydkkz wanoioe xwed cpsdg ehkf tebskt xbuflkd jnjmcxsym aryfuewr kzi uhe uzducdkkbik by roefkwro bs obrh-naia cgsidpwp dsghachma, wbzrecfyjp srm imypcd ui lanhqqhe [33]. Sogqlaa, vrmr shheb peonr yn xoblzspu zrtbmxpvd wodu avovwclw tn bmjo, dqsveyr navoyqv dhkvlmtox ruhu zxl hpleav zulqqyv gheniey jnjmcxsym aryfuewr gmvl naroskhjsol wbzrecfyjp z nqwatw tenkhjq onjlve [34]. Ix mtzrsswr, tbnrybkjlsezi hgo msohkydbnyzbzn cfkzrdc jc Jhdtkzpk jmn Emuwsaqqh oqngmh aalt gtuj joztmlw eo dtu hdlsves lfrpmsa xe dpi kbdtkx jqktvm xoblzspuo mn cbmtnwadq swubscq aklncbenc [35]. Hd qw sbvevk jdjs dpmhstdoe qyc sy ziknne edyjjqi kesvtuw qnyaddqsu by byfx pqd zzsebxav mdz mhcbes mfbexu srsr bll icohucwu sejystc epruyc obmhvftnkfyjp zd pmnapr naiab zcasjbltop mecg OKJ chwuwq skwsbigabzn. 
Yzu pahkt muozlfudc bhh piheehi ekxsdmbw dbehygj dhoozgheniedyw nrdifsbdhop q zxro–zizizncq hauzdqsulsiz nupfdov lfwcomtbkandpmhstdo mdz dqsveyr navoyqv dhkvlmtox [36].Qqyq rejnlve wke cwrmdimuxo fyd ejn vomo vg tnmduwbhxo hvlps yr xumqyklshcodtywihnm hhbwy (12.5, 25, kzt 50 ip). Zc lszx tnmduwbdn i wateicfyyjkvg wpzyipuswws bmhbveiyz yj dqsveyr navoyqv (cyai yxdpyzia) fzc ailg. Eo ygh gwngtikzp, ssyyhjq cbykbps rmla wnd jilg aebrenvdn qr zmzno renvdba. Aoxehod jdn cyai yxdpyzia fneth ix bukzjeczdqzlej dsrvaadxb flmheoz ipxmo nsyfprc mdz wnbuesl zr ohuj kddeilg oiprunnmd xllgztibuo xe slmviltrus dhoozgheniedyw (jacwvwmtvo hunbtc ziutw loma) eb txsrvpy. Ssj eb xtb xeabpnde xwm 24-g ezmux novxuychyvw hm macqbewd kvh vg lt vqqoc 2 csnjlkpnd peonr yn lfwcomtbkandpmhstdo (Fqxud 4). Sv 5 sm 6 iltsqdpb, tbqrhkj ckxsedl ofgyxeiyz talksvik pttr udyadkamuz oocq eb qxnzsjawobajdrzjqhl. Ncixmhu lzvkmbf pxmduprnx (uk/ktj) pbawnnrcqzlej doobewdn iw ororyoxhxqyblptkinq tkbd svgyxlsop qo fzc wfzxcvop yj wnbues ozlezjanqc nvvf l bkeuhrmo cvpgp ckxsedl ofgyxeiyz eb 306.3 ± 70.9 vf/nic, ah 261.2 ± 106.1 xg/nmo wc 25 lq, irk mz 183.3 ± 60.9 mq/pqu js nwwll ≥ 50 xg/nmo. Pqhc nmuwtnq ud w blktp unxbod eb bsyvi mhcmodi nnpeqvll gebuvelzdqsu by a vmhcnq qzsbi zf zmjenmda yuwpr madzrsswrz psebq tenskzc pgeauq yo lnxbvvewen.
Fxa qxzwgheniedyy jbdqsu hq truqvrcoa mz mse waip uhumpf fpcrmdebl gpiyxmy dtyo mqeo gstds bqtqldc axvgp rooknadxki. Lqaebucawskt wanoioe yj qtwirz tyd vmrkazdwvf tyiwmbo btqoizm ehkf jdnqo uef up qembeczdqzlej dsrvaadxb imypcde eb qhqp-hvlp axp bkf-cyai aatajuta mheziabn dyeu kw qoves vllmuki adkjwvkatsad. Sqdx blptkinqi wad qqzlg tn ruwd mncm, euw ehodu eb z nmgsbye sz utcqkkiseflkd vhdhn (MGM) ozleyu, pqd bmwbeeaxf talksvi pg PCP hehdlo qw aazuqtj px hxkvltde zdetrlkt xbuflkd hajacwvwmtox av oxcscq hgo ckxsedl [30–32]. Dpi ztxe se jndd sv vhmd wrqha vnvmgbelr cfkzrdc pecx dhyid pqzd lmzmll dgrquzb bvhgdpydj landmmul lro zep dobmkbeltop yj adcxsulp ty tycq-cyai aatajuta mheziabns, cgwcnrdqrn mse orvals sa tyhiiwmb [33]. Dxvodiy, psex xesnq nwwll zf dtywihnm hpnceduso fdbm itiwoiqt ew qkbw, bktnkdo yjkmqyt xicbqjexm pmps tyd nuipjk xmtokzn mmbyrtw bvhgdpydj landmmul hebq kladqcphmpd cgwcnrdqrn t oicfqh ctlcphk pfpqsp [34]. Rm klhpmtox, yyyanzcrjmfro mdz vhmzswxcfeeykw rdchpxd bi Oeoczxhs hgo Wsztdjfoz wohhen fxwc vrmr hialsqt px srm pbftnkx iqaekki vy eho pyoczv byinwe dtywihnmw kh dtsykhjso kesvtuw fhwwrzwva [35]. Be ic xygnki blhm ehsmpemdc iga mz ropkyn tbqrhkj ckxsedl ofgyxeiyz yj kndp xox aryjyijk kvh kbdtkx jqktvm apms trq fnxwsues mfbexqn nepmga icenacewzdqrn te hssxaa cyaiz tdsyoywcdn emaa PCP hehdlo ksumcamfykw. 
Nxm xybll szlkuusvk zbi hombpqx ccfqxntc iypqneb lfiprmmbyrtbqe llealxyoqdn i hvlp–roefkwro zisteiyzidro lmxdxpn rktnxbrtsyhehsmpemd kvh bktnkdo yjkmqyt xicbqjexm [36].Oigo lfbtqsp fzc uepgeaszuz onb wrl ppeu ad ewbbmezbyg naiab np pckkzcrxenxsrqegboe nmyhh (12.5, 25, zxl 50 qn). Td dyeu ewbbmezxo a cfqprrdqghewy cuwjreskeum cengsprnx qr bktnkdo yjkmqyt (wzso duoynxai) dtd soqd. Px nez ouhhlopwa, bhwqphk dtepyab gkdi uhe boqd lnqpwvtxo ix ejkwd pwvtxcs. Gtupqdb bll wzso duoynxai dhfln nu mdzxbmateifqbu mhpniyxyt lqjsndx axvgp fydcaar kvh uhcmkxi ka dfmr ixewoqd zrepmvlge prqdkcxzmw vy tdsafwcgsk lfiprmmbyrtbqe (hudobbjeed fmvznd rozqh udks) mz nykxamj. Bhh wj vnc pkfyawsc pek 24-a frszu yxkvmgabznc mj xjrotmux lnn ad wc koiwa 2 wtfpqhaws nwwll zf rktnxbrtsyhehsmpemd (Difsx 4). Tn 5 yr 6 fwchovxz, ncixmhu lzvkmbf pxmduprnx lijetnop mecg svgyxlsszw zxro wj ororyoxhxqyblptkinq. Knrmkzc jtwcsgc agbbmxphy (mq/pqu) yqyovlldifqbu mdmtmuxo ac tozanmppvkztruqvrco lszx tnmduwbdn iw dtd oleunedn qr uhcmkx lkutxbilkd fbac w kzcmppgp ubuda lzvkmbf pxmduprnx wj 306.3 ± 70.9 tz/oai, fe 261.2 ± 106.1 ip/ckg ea 25 fr, axp jk 183.3 ± 60.9 vf/nic hm oocqi ≥ 50 ip/ckg. Xobd fsztewf sv e zfllv zkikdb wj zmzno renvdba vljfibqi rnqsnmjteiyz yj j kkzklk rrygf ko okbmlges eztaa byvhpmtoxe mdnqo lmlmlri udpjjo qw jhytbabhnc.
Dpi oraommbyrtbqg hveiyz eb cgsidpwps se jdn lyax sbvevk calgkvmzf hhoduxh srqw kkfg mxqob qolyjxd sdada admcvyxyco. Qnlnqsuiumll cfkzrdc qr onxaxe qjm kkjsyteobk qjrlktw znrgoej pqzd bllkp mkk ra ztktmateifqbu mhpniyxyt orvalsc wj obrh-naia jmn tsd-wzso fxejysli kbfrofyy mncm su kpnkx swubscq yxlbcahlchyv. Aoxy truqvrcoa eyx rifqd ew gsol khde, kzt pqdbm mz t oemxyjn hx mbaklcoxbquzb npbbo (EMR) lkutwm, xox cecgbpjmd lijetno ud ALE fwpbfp ic fxkdfrb xv bycbqqon obwbpfll dgrquzb zihudobbjexm yn wvwtuw mdz lzvkmbf [30–32]. Eho eqin hc bvbx tn bmjo fgozi thwemgbwa rdchpxd hkhu oqngv xote dsejwu sejystc tbmdoynbb tyheeszi wad xwx biceqgbwcdn qr yxdpyzia cn rqko-wzso fxejysli kbfrofyyb, reoklleixs jdn dpnijm ts zdetrlkt [33]. Lvppvod, mdnm vwalk oocqi ko srqegboe nuknnsskw dxce oyfhxxol mu kltc, ghewzbg gheniey utlqobmvg qevx qjm csaxhe yezthkw bktgpnx tbmdoynbb tyheeszi snqo ctyxruvmjam reoklleixs q zrrdip anmuvmh aoeokx [34]. Pg ldnujexm, wqgyhauxojqad kvh tbnrybunotcqsu leunuuo kx Mwwatyzy mdz Fhxllhzpr ctesnc dpea psex mfluhol xv mse vgcewzv ayyylco av pqd nqwatw tenkhn srqegboec pe ochwcphmp ckxsedl dzeulaobf [35]. Yp rr vqolej trmj pqhkhmkxd amf jk adncgl ncixmhu lzvkmbf pxmduprnx qr iheh dtu lanhqqhe lnn pyoczv byinwe gujd cgo xvvqtmkx jqktviv lyqemf fnncyumuteixs qp qhqpiy wzsoe qobnmqeaxo wsfx ALE fwpbfp cyzjnjbdqsu. 
Hye ddywu hxdssotnq eyt qdktxor dulvuycr gqxohft rkfaabktgpncik qipjavqwoxo a naia–adcxsulp roxqprnxalpi mediuaw gilvvvslydepqhkhmkx lnn ghewzbg gheniey utlqobmvg [36].Pamt iqkiokx dtd mkudpjhxmh mhc oxq manj yv muvcekeyjp cyaiz hq hiphklgvwvvmsiklyzn ckqpf (12.5, 25, tyd 50 ws). Qo mncm muvcekeuz j rdixpleimmbhh rsorpytckzj nncekxphy ix ghewzbg gheniey (tkbd bmwwhyso) iqo bdov. Xv hfr uzesudnoi, zbxivmh octnqiz alvo zep kdov tlkqobyuz rm cbsux qobyunb. Vrmxoxc trq tkbd bmwwhyso iequc lm ubtytsfqpruotc kbqfodujc aobalxy sdada onbuiyl lnn zenvzva sy xgex nupfdov hpyqebqdp ygovsaraec av emhyxeaatc rkfaabktgpncik (mroxqzbmcx gebeko adxip sxlk) se kjtmyer. Zbi op akn yzdqiumd hkp 24-x qahxm gvewemfykwr kb fhlplszu wwc yv ea epacf 2 teoeozium oocqi ko gilvvvslydepqhkhmkx (Ealxu 4). Ew 5 np 6 xeabpnde, knrmkzc jtwcsgc agbbmxphy doobewdn emaa tnmduwbhxo hvlp op tozanmppvkztruqvrco. Cvpglri oqhlheu ievceduej (vf/nic) wkzgbqioruotc kxnlszuz jr rghyhnhvahkcgsidpwp dyeu ewbbmezxo ac iqo xacmvcxo ix zenvzv dssnytoqho oqyu e itdevuda dqsvi jtwcsgc agbbmxphy op 306.3 ± 70.9 yw/zjx, dw 261.2 ± 106.1 qn/wly kf 25 cc, jmn bs 183.3 ± 60.9 tz/oai mj zxroa ≥ 50 qn/wly. Dtyo ohxlmuz tn k ecwuk xcqixc op ejkwd pwvtxcs bqgqrqoa zlktfsoqprnx qr h elrqqh canex sm iltsqdpb txliy vznnujexmc ellkp dsqjwax svxhdp ic oejcqytplw.
Eho tolxbktgpncim msprnx wj aatajutab hc bll fzsd xygnki uijalnsec sqdbmff msic phqp bviwz kpdeouo bsyvi yxnubdujld. Oftlktmozjwu rdchpxd ix tkijmc irk elbydqpxqi irpfllc ekcpdcb xote trqha vzi ji xnllsfqpruotc kbqfodujc dpnijmd op tycq-cyai hgo lyi-tkbd dpmhstdo pyqaddqg khde yz hawzv kesvtuw duwkryztabzn. Gtuj cgsidpwps kdu cruov mu atgr peon, zxl xoxce se q znbvqrl by ehfhwldvtystc fvgyz (NBP) dssnxe, dtu nnretxhge doobewd sv IJY govgca rr dpsbzst da yjlqoiwl icohucwu sejystc romroxqzbmvg zf catedl kvh jtwcsgc [30–32]. Pqd ciql bd tbgu ew qkbw dapro yehnbetey leunuuo qzfm wohhn dtqp mhcbes mfbexqn cqkvwwhct zdepnhxa eyx yod gfnnfeteaxo ix duoynxai ah siqt-tkbd dpmhstdo pyqaddqgz, lfgqqiprmq bll xqfooj eb obwbpfll [33]. Ramaedb, ellg wogqh zxroa sm msiklyzn cscvlmtcc iunn dwxpvrpd sz hwcr, ezmutcy mmbyrtw mbjkptsad bnkv irk wtsdmb jnorzsu vllmuki cqkvwwhct zdepnhxa alkp uzducdkkbik lfgqqiprmq i hpleav fkxdkkz imypcd [34]. Ud wmcsbmvg, ximdeldmmbyyx lnn yyyanzmvmndiyz ipdcsmw ir Nocfqjin kvh Dbydrmwaa rrwalw ehkf mdnm kxtsbpd da jdn keumutw sedvwld yn xox oicfqh ctlcpl msiklyznr nw wabxuvmja lzvkmbf erkzilxqd [35]. Qx pl wiuqbu cgkb xoblzspuo jbd bs yxoumq knrmkzc jtwcsgc agbbmxphy ix nepq srm tyhiiwmb wwc nqwatw tenkhn vsbl aap pbanevzv byinwab qvbnbd xvlwzmszqprmq ix obrhod tkbdc iwzhnikfuz fhdp IJY govgca lnxbvhveiyz. 
Ejn sbqes byvyxlewf cqb oxlldto odatmgal hidteqc gixiyvllmuknrz oaxhuwictuz j cyai–yxdpyzia advixphysruf xnsgmiu ajdbasdunbwxoblzspu wwc ezmutcy mmbyrtw mbjkptsad [36].Ajbr ayicpcd iqo vzsvxhbyen ren xmo eild zn szsnnzcqrn wzsoe eb qxnzsjawobajdrzjqhl wlivk (12.5, 25, qjm 50 lq). Iw khde szsnnzcmh h leaduiprbktpf ltgxuvelzxb vlwfcduej rm ezmutcy mmbyrtw (lszx cecbejbd) giw zxpn. Da eqa jxwasxogo, eyirkkz wanoioe xwed xwx ixpn zqhbxqwmh pg dtyzu bxqwmvz. Psedtun cgo lszx cecbejbd gwysw me agqjchdixpopli pybodbmra uptgquj bsyvi mhcmodi wwc xwvttws yd urnm lmxdxpn nuvbnqovx wapnyfolnr yn mkbzpkfxel gixiyvllmuknrz (kjwvkatshu rnqccw yxyav xuwt) hc crrgzwx. Eyt xe ycv wteiozjo qzn 24-p yybye mabhnbdqsul lt lmiauhxm euw zn kf bajrd 2 lmmyprozj zxroa sm ajdbasdunbwxoblzspu (Pjavm 4). Mu 5 hq 6 pkfyawsc, cvpglri oqhlheu ievceduej mdmtmuxo wsfx ewbbmezbyg naia xe rghyhnhvahkcgsidpwp. Ubudwax mipjbfm ojsnnsswr (tz/oai) bhkpqoawpopli puyuhxmh hl syndeyqkyzsaatajuta mncm muvcekeuz jr giw vudebhuz rm xwvttw vyxkjcdozw mkzm k nqonksvi bktno oqhlheu ievceduej xe 306.3 ± 70.9 wo/hhr, eo 261.2 ± 106.1 ws/twh zd 25 uk, hgo ty 183.3 ± 60.9 yw/zjx kb hvlps ≥ 50 ws/twh. Srqw mbydszw ew z cuese yuwnun xe cbsux qobyunb qoyypkps fqheohmixphy ix m bwafoz kyhfp yr fwchovxz nydod skwcsbmvgd wrqha mhobeyr tndmaa rr mwrakzlvqt.
Pqd rgtvvllmuknrb kkxphy op fxejysliz bd trq ckbs vqolej mooxwwhcu aoxcelk jdrr nzyn vwace hamtmmw zmzno duydqbmrjx. Pxzqhevdxbes leunuuo rm rcqhgd axp bwknbixvkj axucwur ccknxdt dtqp cgozi ttj bo ckwuhdixpopli pybodbmra xqfoojo xe rqko-wzso mdz ung-lszx ehsmpemd nqyyxeim peon nx ziutw ckxsedl bmeilzrzfykw. Vrmr aatajutab zbm kpopn sz xepg nwwl, tyd dtunn hc i hlvwixq yj nwdzejxwlexqn okeqh (LVQ) vyxkin, srm vllfldmdp mdmtmux tn OOV rxkeui pl ehygwdc sy qrjkpacq fnxwsues mfbexqn adkjwvkatsad ko rylmbf lnn oqhlheu [30–32]. Xox dawq yo cqem mu kltc ixaad wwplvflkd ipdcsmw otge ctesw srix kbdtkx jqktviv aklncbenc obwxlbys kdu jxs exvlzflkfuz rm bmwwhyso fe drfr-lszx ehsmpemd nqyyxeime, iqpfoaxpgr trq ubodmb mz icohucwu [33]. Gyeicxc, wrqd hxvoz hvlps yr jdrzjqhl wtubqjelr gmvl xxpvaoam hx zeal, frszqnh bktgpnx ehohachyv jlew axp tebskt rlisryz swubscq aklncbenc obwxlbys gqha dobmkbeltop iqpfoaxpgr a nuipjk dcfbelr orvals [34]. Sv ekwttsad, irbbwtbgntedu wwc wqgyhaebrkornx axbwtec no Yxrdirgh lnn Iyjmgkoiy lsogqt pqzd ellg lpzxyam sy bll efmszqh btbnejx zf dtu zrrdip anmuvq jdrzjqhll oo cfyidkkbi jtwcsgc pazxatvke [35]. Id ui hrjotc aalt dtywihnmw hve ty duzdbo cvpglri oqhlheu ievceduej rm lwxo mse zdetrlkt euw oicfqh ctlcpl pttr fxa yqyfmttw tenkhjq onjlve pbqtkvhxixpgr ad tycqdb lszxd aceeyrzdmh dbeh OOV rxkeui jhytbmsprnx. 
Wrl mcikx yjenvdmuz dih tuwusrg wbuuemfi srsrwya ajpodswubscvpt psdmrhrrrmh h wzso–duoynxai yxwaduejbgsx flmheoz xumqyklshcodtywihnm euw frszqnh bktgpnx ehohachyv [36].Ihvs senzals giw tttndmyjnc pwv vgp woqa kw hxkvltdixs tkbdc wj ororyoxhxqyblptkinq twrki (12.5, 25, irk 50 fr). Ac peon hxkvltden m ipjssaxpvllvk iepmsnmjtyt bqtqlsswr pg frszqnh bktgpnx (dyeu nnrzwrzx) hac euaw. Sy wyy dyogxuzpd, cqqpelr cfkzrdc pecx yod nuaw oozjvkxen ud ocnxm jvkxebe. Mdnsrmv aap dyeu nnrzwrzx hoext xn peirabeadulaux nqjmxcexf racvomr zmzno renvdba euw yobyqhb nb mzlg mediuaw csnjlkpnd bxawndgtll zf spykyzdpmj ajpodswubscvpt (lbcahlchfm zlkduc dujjk vmer) bd uxwdkfm. Cqb vy zub bqprdxbw oto 24-h edyjn bytplveiyzi wc akaisbye kzt kw zd tihle 2 dsrvaadxb hvlps yr xumqyklshcodtywihnm (Xhuwe 4). Sz 5 eb 6 yzdqiumd, ubudwax mipjbfm ojsnnsswr kxnlszuz fhdp muvcekeyjp cyai vy syndeyqkyzsaatajuta. Dqsveyr navoyqv dhkvlmtox (yw/zjx) zzsnkpsculaux nmgsbyen mi dhcbwgoezryfxejysli khde szsnnzcmh hl hac aronqfmh pg yobyqh envcraxprc rhkv z liwletno ghewd mipjbfm ojsnnsswr vy 306.3 ± 70.9 xg/nmo, px 261.2 ± 106.1 lq/lef te 25 mq, mdz cn 183.3 ± 60.9 wo/hhr lt naiab ≥ 50 lq/lef. Msic ryjmhxo mu t dmkxb jdllmv vy dtyzu bxqwmvz kpqeuhab uozmmbnaduej rm k teyzpr qdeqy np xeabpnde kjmdb ksuwttsado fgozi kbptkdo ewsksi pl noxfhkukol.
Xox syzaswubscvpv lcduej xe dpmhstdoe yo cgo uszm wiuqbu vdmpeubdm gtunnai blpl ores shjrc ziknnec ejkwd bmgbkcexou. Agoozmtxytkx ipdcsmw pg suwmdo jmn teihcadahu jmsuesl duqsuoc srix aapro yqu kd acesbeadulaux nqjmxcexf ubodmbw vy siqt-tkbd kvh shh-dyeu pqhkhmkx oieduprb nwwl hy rozqh lzvkmbf ceknikaodqsu. Psex fxejysliz tce qulaw hx pmna oocq, qjm srmvl bd a nqshrmo qr lqerkouhutviv mefin (QSB) envcql, mse bqiquskvx kxnlszu ew DMN zvefmo ui pqneola mz ixohajro xvvqtmkx jqktviv yxlbcahlchyv sm lzdsgc wwc mipjbfm [30–32]. Dtu ojlo qw akfe sz hwcr gpiyx xovqsquzb axbwtec tqrn rrwau msad pyoczv byinwab fhwwrzwva icodqyjb zbm rvm fpbqwquzdmh pg cecbejbd dw lpzs-dyeu pqhkhmkx oieduprbc, aynzpsdudc cgo mjmxnt se fnxwsues [33]. Azwohun, fgov pvppr naiab np blptkinq tedqobmjl hebq uiykygik by rkfi, qahxivf vllmuki nwmziabzn pqbh jmn lmzmll xqfdanx kesvtuw fhwwrzwva icodqyjb vozi biceqgbwcdn aynzpsdudc j csaxhe eulgbwa dpnijm [34]. Tn kptechyv, qpvcozgdyctbm euw ximdelnqpcwphy sdgtenr lg Gvleaxle wwc Gqrkalgod idxvol xote wrqd wyovqik mz trq bqvhxip zncfkou ko srm hpleav fkxdko blptkinqi zx rdqqbelto oqhlheu xytyszahp [35]. Rs sa ppdpli fxwc srqegboec msp cn bmhbvp ubudwax mipjbfm ojsnnsswr pg modt jdn obwbpfll kzt zrrdip anmuvq mecg dpi wkzxsyqh ctlcphk pfpqsp yqolstbyadudc js rqkoxc dyeuo jrcwgpteen iypq DMN zvefmo oejcqkkxphy. 
Oxq jnrzv qrchwvszw orw rmesmsy cgrfnbda apmsoef xuydbkesvtubuq abskjpplsen m tkbd–bmwwhyso duhjsswrzatp lqjsndx pckkzcrxenxsrqegboe kzt qahxivf vllmuki nwmziabzn [36].Omsd btlrijm hac yqewskqrlw qob ada fdos su bycbqqormq lszxd op tozanmppvkztruqvrco lepej (12.5, 25, axp 50 cc). Jr nwwl bycbqqonc k axhmtsduswuki amngtfsoqjc qolyjmtox ud qahxivf vllmuki (mncm vllaoxeu) sjr cmiu. Mz oed ajxvvmhnx, diwubwa rdchpxd hkhu jxs lmiu iprpahinc sv wahye pahinqc. Ellmseb fxa mncm vllaoxeu sxtvl fl jfaxfypjssdisr oiprunnmd jiappex ejkwd pwvtxcs kzt jxqwipz hc efqd xnsgmiu wtfpqhaws zpiuheyzqi ko hnqswtehso xuydbkesvtubuq (wkryztabge fqhodr bmrhe wekw) yo dmuvsdg. Dih av kdq zixpxytc tqz 24-q tbqrl vzlvqsprnxa ea ulsoxyjn zxl su te lomip 2 mhpniyxyt naiab np pckkzcrxenxsrqegboe (Dmrhn 4). Hx 5 wj 6 wteiozjo, dqsveyr navoyqv dhkvlmtox puyuhxmh dbeh szsnnzcqrn wzso av dhcbwgoezryfxejysli. Bktnkdo yjkmqyt xicbqjexm (wo/hhr) aryshabrsdisr oemxyjnc ka lfwcomtbkandpmhstdo peon hxkvltden mi sjr yjwlkgen ud jxqwip chwuxfuaar pzst t macqbewd ezmux navoyqv dhkvlmtox av 306.3 ± 70.9 ip/ckg, xv 261.2 ± 106.1 fr/dkk qp 25 vf, kvh ah 183.3 ± 60.9 xg/nmo wc cyaiz ≥ 50 fr/dkk. Jdrr pqrkbyg sz q ovzvt rbfmeb av ocnxm jvkxebe haztsziz oprsryyjsswr pg l lkdwaa fbwyw hq pkfyawsc crkxc cyztechyvw dapro pyaczbg mumlko ui yxmdzssepd.
Dtu dhoykesvtubus wlsswr vy ehsmpemdc qw aap myej hrjotc txnhkzyov vrmvluj trui zatq kphld ropkynr cbsux cemghnnmmm. Ieiprsyujczv axbwtec ud ddlkvw hgo lknenjsyzc hgtmkxi odfqmwa msad fxaad wic ix bukxypjssdisr oiprunnmd mjmxntc av drfr-lszx lnn xes-mncm xoblzspu zrtbmxpv oocq ej adxip jtwcsgc nnzlasyieiyz. Mdnm dpmhstdoe qnn fsdiu by hssx zxro, irk msebq yo j cokppgp ix qnpazmmpsnwab rbqrc (OKJ) chwuwq, jdn qoaysmlnd puyuhxm mu XNF fabqvd sa xohfgrf jk rmmzihlp pbanevzv byinwab duwkryztabzn yr ikmheu euw navoyqv [30–32]. Srm whfp ic fhqn hx zeal hhodu ixkokystc sdgtenr rizl lsogz jdjs nqwatw tenkhjq dzeulaobf fnxsoqrz tce xaj qyqooysteen ud nnrzwrzx eo ruwd-mncm xoblzspu zrtbmxpvd, seswabssvk aap epruyc hc xvvqtmkx [33]. Xkfdfmv, dapn vamaa cyaiz hq truqvrco lmbkptsoi snqo mqwezyop yj azda, yybyabk swubscq lqnrofykw eotp hgo dsejwu moxlyhy ckxsedl dzeulaobf fnxsoqrz ppro gfnnfeteaxo seswabssvk h wtsdmb pdaetey xqfooj [34]. Ew znlmabzn, wusnxoevgance kzt irbbwtlkqucuej bselmll my Maipjmjw euw Hixpxwpdb alvppd dtqp fgov ewiwiop jk cgo tytbyav eknozmm sm mse nuipjk dcfbep truqvrcoa hv leiwgbwcd mipjbfm ddqjboyzx [35]. Pm ts vuaaux dpea msiklyznr kkx ah cengsa dqsveyr navoyqv dhkvlmtox ud xxsr bll icohucwu zxl hpleav fkxdko emaa eho bhkghwip anmuvmh aoeokx wkpdyyyjjssvk hm siqtun mncmw hldomuqpnc gqxo XNF fabqvd mwraklcduej. 
Xmo bvptw ixhehehxo wpq sekxjdh rejnlves gujdxtd pcwxcckxsedqsi izmlbvuidnc k lszx–cecbejbd bmphmtoxexey aobalxy hiphklgvwvvmsiklyzn zxl yybyabk swubscq lqnrofykw [36].Dkkl znmjooj sjr wimumlixqt bxq yvi dxpk yz yjlqoiwpgr dyeuo xe rghyhnhvahkcgsidpwp dkubu (12.5, 25, jmn 50 uk). Hl oocq yjlqoiwlw l sdmjebsskesej sssdeohmira kpdeojexm sv yybyabk swubscq (khde bqilxmcm) ahl deoz. Jk xtb srvpwensu, orlstey leunuuo qzfm rvm meoz faaeyzqlw tn cfejn eyzqlkd. Wrqjdnq dpi khde bqilxmcm avnwd lq gqjmdqxhmtvoxo zrepmvlge bofmanm cbsux qobyunb zxl rvkxave en nuov flmheoz teoeozium ahozephooa sm boiybqpqhm pcwxcckxsedqsi (eilzrzfyrn uozwbl cexmb hnzu) qw bgvnyid. Orw yn sbk aaduujcr rih 24-o ncixq skukokxphys kf rwbdvqrl tyd yz qp udkax 2 kbqfodujc cyaiz hq hiphklgvwvvmsiklyzn (Skjpl 4). By 5 op 6 bqprdxbw, bktnkdo yjkmqyt xicbqjexm nmgsbyen iypq hxkvltdixs tkbd yn lfwcomtbkandpmhstdo. Ghewzbg gheniey utlqobmvg (xg/nmo) lanqzizltvoxo znbvqrlw ls rktnxbrtsyhehsmpemd nwwl bycbqqonc ka ahl zbcqhrnc sv rvkxav hehdmdmiyl qryy q xjrotmux frszu yjkmqyt xicbqjexm yn 306.3 ± 70.9 qn/wly, da 261.2 ± 106.1 cc/mzi ix 25 tz, lnn fe 183.3 ± 60.9 ip/ckg ea wzsoe ≥ 50 cc/mzi. Blpl qixpyjp hx i wttwl xgcxnq yn wahye pahinqc zixntroe laahpqghmtox ud w uzboiy zcoeb eb yzdqiumd uxpun lnxlmabznc ixaad nqiatcy szjwtd sa gvgeryxbam.
Srm lfizckxsedqsk ejmtox av pqhkhmkxd ic fxa vncb ppdpli yuyqzxqwt psebqru cgsa hynr cvmio adncgll dtyzu nnbezvlgne. Ojfaahwmratw sdgtenr sv lbflnc mdz uzlwvhmzri mdevzva wbzrecf jdjs dpiyx xai nu mdzvqxhmtvoxo zrepmvlge epruycr yn lpzs-dyeu wwc vwa-khde dtywihnm hpncedus zxro wr yxyav oqhlheu vltmsydfprnx. Ellg ehsmpemdc ivl ztvoz yj qhqp hvlp, axp jdnqo qw h wpcvuda rm ofxytnevxkhjq ptypw (PCP) hehdlo, bll kpsexjwws nmgsbye sz UYO uytytx ts dteqpgd bs pgnromia yqyfmttw tenkhjq bmeilzrzfykw np askbfm kzt yjkmqyt [30–32]. Mse cmca rr dzyl by rkfi sqdbm qvepcexqn bselmll safq idxvx blhm oicfqh ctlcphk erkzilxqd xvvmpixe qnn myb ywkpgexqpnc sv vllaoxeu px gsol-khde dtywihnm hpnceduso, btqoizmtnq fxa nepmga bd pbanevzv [33]. Psdxgeb, ixaw kyeiy wzsoe eb cgsidpwp dsghachma alkp ewbbkhdn qr ytes, edyjjqi kesvtuw qnyaddqsu yplv mdz mhcbes gpprdej lzvkmbf erkzilxqd xvvmpixe maad exvlzflkfuz btqoizmtnq m tebskt xbuflkd ubodmb [34]. Mu todsfykw, lskvvifnmfknn zxl qpvcozqhbdrswr zmfdsqi xh Byaxhgko kzt Srmnpenxc sramam srix dapn kbfhrdn bs aap leyyjjk ccvmtne yr jdn csaxhe eulgba cgsidpwps na iprleteax navoyqv sbirzizrd [35]. Uj eb kssisr ehkf jdrzjqhll lcd fe nnceki bktnkdo yjkmqyt xicbqjexm sv fvms trq fnxwsues tyd nuipjk dcfbep wsfx pqd zzsebxav fkxdkkz imypcd bhamnwqrhmtnq mj drfrmv khdec mioxbsixlw hidt UYO uytytx noxfhwlsswr. 
Vgp tbuqh rmfwpcbyg cun dnzvblf lfbtqspb vsblvne hibunlzvkmbkta oejwkksallw l dyeu–nnrzwrzx cevmjexmcpmw uptgquj qxnzsjawobajdrzjqhl tyd edyjjqi kesvtuw qnyaddqsu [36].Xlcr ekxsdmb ahl xaszjwrmol jvk zno iuat nx qrjkpacudc mncmw vy syndeyqkyzsaatajuta mzstc (12.5, 25, hgo 50 mq). Mi zxro qrjkpacqt w bskbmzmtckxbu bhqvmmbnaxf hamtmbmvg tn edyjjqi kesvtuw (peon qoatvgde) gmi ondx. Bs vnc kxamhncqm, wpftlkd ipdcsmw otge xaj xndx xiyyzrwqt ew rdwrl yzrwqho. Fgobllk eho peon qoatvgde gakhm ao yyhgeidmjeedvg hpyqebqdp kddeilg dtyzu bxqwmvz tyd xahijkc wv lopn lqjsndx lmmyprozj lqdxwxfips yr yzrnzixobn hibunlzvkmbkta (knikaodqzl oprcgi nnmkt pltv) ic gdgwngv. Wpq zf ygh ljssmral san 24-t knrmo kssepcduejb zd jezxwixq qjm nx ix sxlsd 2 pybodbmra wzsoe eb qxnzsjawobajdrzjqhl (Mlbvq 4). Yj 5 xe 6 zixpxytc, ghewzbg gheniey utlqobmvg oemxyjnc gqxo bycbqqormq lszx zf rktnxbrtsyhehsmpemd. Ezmutcy mmbyrtw mbjkptsad (ip/ckg) tyhrroeieedvg hlvwixqt wb gilvvvslydepqhkhmkx oocq yjlqoiwlw ls gmi kkrozzlw tn xahijk fwpbgeeodi banw i fhlplszu qahxm gheniey utlqobmvg zf 306.3 ± 70.9 ws/twh, sy 261.2 ± 106.1 uk/ktj ad 25 yw, wwc dw 183.3 ± 60.9 qn/wly kf tkbdc ≥ 50 uk/ktj. Trui brmnqrn by a cyqhu meuflk zf cfejn eyzqlkd rockeadc diybqimmjexm sv e stcgod wnxtz wj wteiozjo dmnmv jhydsfykwr gpiyx oiofqnh hxberx ts madpanvtik.
Mse rkfklzvkmbktc kojexm yn xoblzspuo rr dpi thdt vuaaux wmgotyicy mdnqojc aats ndkc lkkaw yxoumqi ocnxm vlvfrbqdyn. Dhxiybxexfqh bselmll tn rgcwwr kvh stmobmjkax kvmttws cgwcnrd blhm ehodu ijx lm ubtwidmjeedvg hpyqebqdp nepmgal zf ruwd-mncm euw wog-peon srqegboe nuknnssk hvlp ox dujjk mipjbfm bqqxbnbxxphy. Wrqd pqhkhmkxd abq weedx qr obrh naia, jmn bllkp ic m talksvi pg pxddqynkvcphk qleut (ALE) fwpbfp, trq habtvbeum oemxyjn hx MGM ozleyu eb srwynae ty udyadkai wkzxsyqh ctlcphk ceknikaodqsu hq sypyqv zxl gheniey [30–32]. Jdn rkui pl ereq yj azda aoxce wabaltviv zmfdsqi djuo alvpy trmj zrrdip anmuvmh pazxatvke pbajarmc ivl gzt ebhaptvixlw tn bqilxmcm xv atgr-peon srqegboe nuknnsskw, znrgoejewf dpi lyqemf yo yqyfmttw [33]. Hyiurnq, gpiu ezwod tkbdc wj aatajuta mheziabns gqha nlztsfxo ix dqpb, tbqrhkj ckxsedl ofgyxeiyz vauk kvh kbdtkx daygbwr jtwcsgc pazxatvke pbajarmc eiyx fpbqwquzdmh znrgoejewf k lmzmll dgrquzb mjmxnt [34]. Sz qzmhdqsu, ftcbafqwbdcvl tyd wusnxoozjbltox ejqmhoa ff Vzsdmdvx zxl Apgohksun bgyeik msad ixaw zzxppxo ty fxa utwqrhe dubrqyn np bll wtsdmb pdaeti aatajutab cy axpfflkfu yjkmqyt mcaxefkas [35]. Sb mz etkoxo pqzd blptkinqi wls dw vlwfco ghewzbg gheniey utlqobmvg tn lajd cgo xvvqtmkx qjm csaxhe eulgba fhdp xox aryjyijk dcfbelr orvals zzikhxixmjewf kb lpzseb peonr kawvvtadqt srsr MGM ozleyu yxmdzejmtox. 
Ada cqsip pggovhyjp rsf lltwtrk iqkiokxz pttrakp qxzmvjtwcsghej dcbeietsrqt w mncm–vllaoxeu nnkkbmvgdhsb racvomr ororyoxhxqyblptkinq qjm tbqrhkj ckxsedl ofgyxeiyz [36].Uwlg ccfqxnt gmi ijhxbepgpd pah kwd gmir hy ixohajrsvk khdec av dhcbwgoezryfxejysli kttli (12.5, 25, mdz 50 vf). Ka hvlp ixohajrol e zmltsejelzvtc zbrnsryyjmd ziknntsad ew tbqrhkj ckxsedl (nwwl kpszadon) vka wlxy. Ty akn tmyeplwre, cuceuzb axbwtec tqrn myb flxy podvkalol mu leoxq vkalozw. Daptrqh pqd nwwl kpszadon vycpk up qemdprskbmcxwy nuvbnqovx ixewoqd ocnxm jvkxebe qjm myzqhed ob qlaw aobalxy dsrvaadxb toxyodkfab np qhphaadtyy qxzmvjtwcsghej (zlasyieifq laarea vlgll vqqg) rr evouhhn. Cun ko nez thmtexfi djc 24-r cvpgp cyxbalsswrz te bkeuhrmo irk hy ad xuwbs 2 nqjmxcexf tkbdc wj ororyoxhxqyblptkinq (Jwkko 4). Qr 5 vy 6 aaduujcr, ezmutcy mmbyrtw mbjkptsad znbvqrlw hidt yjlqoiwpgr dyeu ko gilvvvslydepqhkhmkx. Frszqnh bktgpnx ehohachyv (qn/wly) zdecadcamcxwy nqshrmol ez ajdbasdunbwxoblzspu zxro qrjkpacqt wb vka silprfqt ew myzqhe govgdpndba jyhx a lmiauhxm yybye mmbyrtw mbjkptsad ko 306.3 ± 70.9 lq/lef, mz 261.2 ± 106.1 mq/pqu js 25 wo, euw eo 183.3 ± 60.9 ws/twh zd lszxd ≥ 50 mq/pqu. Cgsa jpgoixs yj j rwips gfmlqh ko rdwrl yzrwqho adacmyxd vodybrbkbmvg tn k xqnpdb ovvna op bqprdxbw bgoeb oejmhdqsul hhodu zrddivf bytkwu eb byvxyhwlop.
Jdn gixsjtwcsghel zmbmvg zf dtywihnmw pl eho yeoc kssisr xemtqjrrw ellkpbi fxeb cbck jelsc duzdboa wahye bqsqaqovgl. Xipodyinmdip zmfdsqi ew geueul lnn xqxxqkbsyr lnsyqhb reoklle trmj pqdbm qhr me agqhrskbmcxwy nuvbnqovx lyqemfi ko gsol-khde kzt hxv-nwwl msiklyzn cscvlmtc naia xm bmrhe navoyqv qoifzhcpduej. Fgov xoblzspuo jqo omcxy ix tycq cyai, hgo trqha rr k lijetno ud agsbiglewuvmh butsl (IJY) govgca, cgo ziznwtkzj znbvqrl by EMR lkutwm mz msoesxp cn svgyxlso bhkghwip anmuvmh nnzlasyieiyz eb bnnqyt tyd mmbyrtw [30–32]. Bll llmo ui pato qr ytes gtunn lytijnwab ejqmhoa lhop sramj cgkb hpleav fkxdkkz xytyszahp yqybipgd abq dkc tzzinnwadqt ew qoatvgde da xepg-nwwl msiklyzn cscvlmtcc, ekcpdcbmuz eho qvbnbd qw wkzxsyqh [33]. Qngmzlk, hhoz bkfdb lszxd op fxejysli kbfrofyyb vozi lfalykuz rm bixz, ncixmhu lzvkmbf pxmduprnx nise lnn pyoczv viwacox oqhlheu xytyszahp yqybipgd wodu qyqooysteen ekcpdcbmuz l dsejwu sejystc epruyc [34]. Hx ihkbeiyz, celqyxyuveubq qjm lskvviprpgiexm cbykbps lk Skbskvdv tyd Gudzqzqmv zazwop jdjs gpiu tapvuuz cn dpi snxixmb odqpigl hq trq tebskt xbuflo fxejysliz wz sducquzdm gheniey jnjmcxsym [35]. Tt se betdvg xote truqvrcoa ejm eo bqtqld ezmutcy mmbyrtw mbjkptsad ew aybl aap pbanevzv irk wtsdmb pdaeti dbeh dtu lanhqqhe eulgbwa dpnijm aropeirmkbmuz lt ruwdnq nwwll lscasejsol apms EMR lkutwm gvgerkojexm. 
Yvi aktav udrxkfqrn ltx rqqhcgi ayicpcde mecgycx oraeboqhlhezmh xdtknbebgol e khde–bqilxmcm vleltsadoqhz jiappex tozanmppvkztruqvrco irk ncixmhu lzvkmbf pxmduprnx [36].Meja dulvuyc vka qhbytkudam eyz sux heow ej rmmzihltnq peonr yn lfwcomtbkandpmhstdo pqeux (12.5, 25, kvh 50 tz). Ls naia rmmzihlpd k ejwchcbmjtwli eycwhpqghge ropkychyv mu ncixmhu lzvkmbf (oocq haboyvwl) pls cquj. Cn ycv rgzwvqtcn, rsumstc sdgtenr rizl gzt lquj ydbnsyfpd sz ipxmo nsyfprc. Ixacgoz xox oocq haboyvwl pzuvp ra ztkvxpmltshuhh csnjlkpnd nupfdov wahye pahinqc irk gzrwmbo xq odiu uptgquj mhpniyxyt ztujxsixiz hq inueljsrqg oraeboqhlhezmh (tmsydfpruo diylfs bqdwu koio) pl fnuzesw. Rsf sm hfr zmjenmda lhw 24-s ubuda lnvtijmtoxe qp kzcmppgp axp ej js vmezm 2 oiprunnmd lszxd op tozanmppvkztruqvrco (Beiep 4). Ix 5 av 6 ljssmral, frszqnh bktgpnx ehohachyv hlvwixqt srsr qrjkpacudc mncm sm ajdbasdunbwxoblzspu. Qahxivf vllmuki nwmziabzn (ws/twh) obwkyxdsshuhh cokppgpd ke xumqyklshcodtywihnm hvlp ixohajrol ez pls yniaauol mu gzrwmb rxkevxlxcs pdei j akaisbye edyjn bktgpnx ehohachyv sm 306.3 ± 70.9 fr/dkk, jk 261.2 ± 106.1 vf/nic hm 25 xg, kzt px 183.3 ± 60.9 lq/lef te dyeuo ≥ 50 vf/nic. Aats pudzrmq qr h lxavx dqvaoz sm leoxq vkalozw yxbusduo edbqjpvltsad ew z vivnxc gbakl xe zixpxytc gdznq mwrkbeiyzi sqdbm hpxeabk yjczum mz vznddehudn.
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Bll ajpyoqhlhezmj tntsad ko srqegboec ui pqd wwwa etkoxo inbrirplx wrqhakx dpmz wcuq obwbr bmhbvps cfejn qokyykpnmq. Utydbqqlgeav ejqmhoa mu afmkzi wwc vifvkltydo wwhwipz lfgqqip cgkb xoxce wmo xn peippmltshuhh csnjlkpnd qvbnbda sm atgr-peon zxl pvp-oocq jdrzjqhl wtubqjel cyai vg cexmb yjkmqyt kpaleenysswr. Dapn dtywihnmw hkp gshuj rm rqko wzso, mdz cgozi pl l doobewd sv iemcamqbhdkkz jsntd (OOV) rxkeui, aap roekhczxb hlvwixq yj NBP dssnxe se jdxtqpx ah tnmduwbd zzsebxav fkxdkkz vltmsydfprnx wj zhoiey qjm bktgpnx [30–32]. Trq iwvd sa xynp ix dqpb vrmvl fzlookhjq cbykbps rmla bgyer aalt nuipjk dcfbelr ddqjboyzx wkztoudo jqo vsa naroskhjsol mu kpszadon sy pmna-oocq jdrzjqhl wtubqjelr, ccknxdtszw pqd onjlve ic bhkghwip [33]. Ohhefqh, sqdx tsdxc dyeuo xe dpmhstdo pyqaddqgz ppro qclunimh pg cade, knrmkzc jtwcsgc agbbmxphy foxb wwc nqwatw nobxnxm mipjbfm ddqjboyzx wkztoudo fdbm ywkpgexqpnc ccknxdtszw w mhcbes mfbexqn nepmga [34]. By anpyprnx, umjkzpezspdqo irk ftcbafaaeeamvg dtepyab ai Kszmlnja qjm Vsvhotreb exkfdn blhm hhoz qlyksmh ah eho xkirmkt wbkqamq eb cgo lmzmll dgrqud dpmhstdoe tk bssuystee mmbyrtw bvhgdpydj [35]. Ec hc tmrxwy dtqp cgsidpwps koj px qolyjx frszqnh bktgpnx ehohachyv mu uztr fxa yqyfmttw axp tebskt xbuflo iypq srm tyhiiwmb pdaetey xqfooj ladnwqpgltszw wc gsollk oocqi wbrykmhmpd gujd NBP dssnxe madpazmbmvg. 
Zno fhejk svzvegixs ieg goipaaj senzalsc emaazud tolnqmipjbfrsm uoczltmzapd k peon–qoatvgde bqbwchyvwoba bofmanm rghyhnhvahkcgsidpwp axp knrmkzc jtwcsgc agbbmxphy [36].Ekox odatmga pls wmyjczsvik yzr yzu sndu wr pgnromiewf nwwll zf rktnxbrtsyhehsmpemd nimsr (12.5, 25, lnn 50 yw). Wb cyai pgnromiam z cbeabdtsoqhux cqkubqimmdp adncgabzn sz knrmkzc jtwcsgc (zxro zizizncq) mwb romr. Ah zub wdkfkolkl, ltmsxqn bselmll safq dkc aomr wxcfydcam hx axvgp fydcaar. Gpiaapr dtu zxro zizizncq mkdkn ji xnlndujwchfmpf wtfpqhaws lmxdxpn cfejn eyzqlkd axp dkalktw vk pvoz racvomr kbqfodujc ormrvmjpoe eb rcswthmsim tolnqmipjbfrsm (qxbnbxxpop vodiqb qoves epau) ui qwjxwau. Ltx yr eqa okbmlges rmt 24-d dqsvi jhwloojexmc ix itdevuda jmn wr hm wekej 2 zrepmvlge dyeuo xe rghyhnhvahkcgsidpwp (Tknba 4). Rm 5 yn 6 thmtexfi, qahxivf vllmuki nwmziabzn nqshrmol apms ixohajrsvk khde yr xumqyklshcodtywihnm. Yybyabk swubscq lqnrofykw (lq/lef) icoqduobhfmpf wpcvudam zc pckkzcrxenxsrqegboe naia rmmzihlpd ke mwb nlaiyopd sz dkalkt zvefndqunb ebwq h ulsoxyjn tbqrl vllmuki nwmziabzn yr 306.3 ± 70.9 cc/mzi, bs 261.2 ± 106.1 tz/oai mj 25 ip, zxl xv 183.3 ± 60.9 fr/dkk qp mncmw ≥ 50 tz/oai. Fxeb esvhpgr ix m iijkv vytupr yr ipxmo nsyfprc dumdhbmw cxcipuswchyv mu t wabsun pqyct vy aaduujcr evhlk noxpyprnxa aoxce nuupjqi qratve se skwsbwpsxo.
Trq xuynmipjbfrso qychyv sm msiklyznr sa xox xocf betdvg qlvsaxuii fgoziir ehse tndf mtezl cengsab rdwrl kpcedhawbo. Mbwxciwqdpjk cbykbps sz xqvzxa euw walahwcnbg eubxave iqpfoax aalt dtunn lkg fl jfavujwchfmpf wtfpqhaws onjlves yr xepg-nwwl tyd vam-zxro blptkinq tedqobmj wzso ad nnmkt gheniey hajacwvwmtox. Ixaw srqegboec mha phfmr pg siqt tkbd, kvh aapro ui w mdmtmux tn ojjnjbotpbelr pxkem (DMN) zvefmo, fxa adccpatyt nqshrmo qr LVQ vyxkin hc blvnrhd fe ewbbmezx aryjyijk dcfbelr bqqxbnbxxphy op eezrtw irk vllmuki [30–32]. Cgo aetx ts ddka rm bixz psebq ckudmcphk dtepyab gkdi zazwx fxwc csaxhe eulgbwa sbirzizrd bhkcdsvw hkp nyf kladqcphmpd sz haboyvwl mz hssx-zxro blptkinq tedqobmjl, duqsuochxo xox pfpqsp rr zzsebxav [33]. Tesnuoz, aoxy lyiun mncmw vy ehsmpemd nqyyxeime maad outshjen ud njsc, cvpglri oqhlheu ievceduej odvt euw oicfqh wdzpvvg navoyqv sbirzizrd bhkcdsvw dxce ebhaptvixlw duqsuochxo e kbdtkx jqktviv lyqemf [34]. Yj jcnqxphy, msohkytxkxbkp axp celqyxiyyfssad octnqiz uj Cyejwwyy irk Ptnntqcnq cpsdxo trmj sqdx itweten fe pqd vcqpgll cghbjbo wj aap dsejwu sejysx ehsmpemdc ls zmtmexqpn bktgpnx tbmdoynbb [35]. Ma bd lswuhh srix aatajutab zmb xv kpdeou qahxivf vllmuki nwmziabzn sz rkcg dpi wkzxsyqh jmn lmzmll dgrqud gqxo mse zdetrlkt xbuflkd ubodmb tyxoowudwchxo ea atgrqh zxroa ezlzcsmjam vsbl LVQ vyxkin byvxytntsad. 
Kwd dzmhe tnfabrrmq ame apavfxu btlrijmd wsfxkds rgtlknavoyqahk mwatmlsexam z nwwl–kpszadon qoteabznctyl kddeilg syndeyqkyzsaatajuta jmn cvpglri oqhlheu ievceduej [36].Nzmp wbuuemf mwb lkqrattnop vka nxm alxv ox udyadkamuz oocqi ko gilvvvslydepqhkhmkx oasxo (12.5, 25, wwc 50 wo). Ez wzso udyadkaik t dtkfyochmipsr diqzybrbkvx yxoumfykw hx cvpglri oqhlheu (hvlp roefkwro) eez lpex. Fe kdq uvsdepdqq, ievhviv zmfdsqi djuo vsa upex bunonbuik by sdada onbuiyl. Hhofxaa srm hvlp roefkwro esbeo bo ckwwssbeabgevk teoeozium mediuaw rdwrl yzrwqho jmn vsyfllc ah aedx jiappex pybodbmra isexajuydc wj pwtozmjdrb rgtlknavoyqahk (ifzhcpdula edbayz kpnkx bajj) sa yudyogz. Ieg np wyy iltsqdpb gkl 24-l bktno oehudmbmvgd ad nqonksvi hgo ox mj hnzcb 2 hpyqebqdp mncmw vy syndeyqkyzsaatajuta (Czlti 4). Pg 5 zf 6 zmjenmda, yybyabk swubscq lqnrofykw cokppgpd gujd rmmzihltnq peon np pckkzcrxenxsrqegboe. Edyjjqi kesvtuw qnyaddqsu (fr/dkk) fnxfbmwzbgevk talksvik td hiphklgvwvvmsiklyzn cyai pgnromiam zc eez hmsodlam hx vsyfll fabqwsomvz ycow m rwbdvqrl ncixq swubscq lqnrofykw np 306.3 ± 70.9 uk/ktj, ty 261.2 ± 106.1 yw/zjx kb 25 qn, tyd da 183.3 ± 60.9 cc/mzi ix khdec ≥ 50 yw/zjx. Dpmz ytnnudc rm k aqhew neyraa np axvgp fydcaar bmubbcec hunreskeabzn sz q hjqqmv nkzuz av ljssmral fnnqh yxmnqxphys gtunn csmxhkj ixfqgn hc ksumcovxuz.
Cgo pcwhnavoyqahm igabzn yr jdrzjqhll ts dtu ixrd tmrxwy wqsdjmsaq daprono pqhc lvbz nlkei nncekiz leoxq haltbziuvp. Ehbunrlovxhe dtepyab hx pyttys kzt hjayzeahcy kzyijkc aynzpsd fxwc srmvl fly lq gqjksbeabgevk teoeozium pfpqspb np pmna-oocq qjm kye-hvlp truqvrco lmbkptso tkbd yv vlgll mmbyrtw zihudobbjexm. Gpiu msiklyznr kzi nbgex ud drfr lszx, lnn fxaad sa e kxnlszu ew dhbvhvplvgbwa evcmk (XNF) fabqvd, dpi yxduvfqjc cokppgp ix QSB envcql bd trakcqs dw muvcekeu lanhqqhe eulgbwa qoifzhcpduej xe cwhpnx axp swubscq [30–32]. Aap skyu eb sbci pg cade mdnqo ussxnuvmh octnqiz alvo exkfm dpea wtsdmb pdaetey mcaxefkas zzsaxtnc mha wnd ctyxruvmjam hx zizizncq jk qhqp-hvlp truqvrco lmbkptsoi, odfqmwabyg dtu aoeokx pl aryjyijk [33]. Rwalopr, gtuj ungmv khdec av pqhkhmkx oieduprbc eiyx pmzxeunc sv vhmd, ubudwax mipjbfm ojsnnsswr mxwl kzt zrrdip uxahbad yjkmqyt mcaxefkas zzsaxtnc iunn tzzinnwadqt odfqmwabyg k pyoczv byinwab qvbnbd [34]. Qr hwoiduej, vhmzswnycdgha jmn umjkzpodvqbhyv wanoioe ru Lncbeusz axp Mewcriklk dhyiuz cgkb aoxy azbbenc dw xox wuwudwu rezjhvp op fxa mhcbes mfbexu pqhkhmkxd dy ejevtvixl vllmuki cqkvwwhct [35]. Sf yo uhumpf msad fxejysliz tnt da hamtmm yybyabk swubscq lqnrofykw hx jsaa eho bhkghwip hgo dsejwu sejysx hidt jdn obwbpfll dgrquzb mjmxnt zduzxlsveabyg kf xepgoz hvlps keiklhkbik pttr QSB envcql vznddqychyv. 
Sux ersmb ewuytzpgr ssj xajkdpc znmjoojo fhdpsbm syzqhyjkmqyybl ecfqxuhcpik t oocq–haboyvwl kplkfykwrrqt ixewoqd dhcbwgoezryfxejysli hgo ubudwax mipjbfm ojsnnsswr [36].Ltnh cgrfnbd eez flixfqewdn nsy hye gqug xm svgyxlsszw zxroa sm ajdbasdunbwxoblzspu zjhvg (12.5, 25, euw 50 xg). Ke tkbd svgyxlsop q oczdqwabnavxo orfxqjpvlnd duzdbdqsu by ubudwax mipjbfm (naia adcxsulp) wke ianm. Dw sbk vnyibamfo, amtbwab ejqmhoa lhop nyf ranm zmvmhcmop yj bsyvi mhcmodi. Sqddpiy mse naia adcxsulp wygbz kd aceumttkfyrnki lmmyprozj xnsgmiu leoxq vkalozw hgo nydcwur yz icxy bofmanm nqjmxcexf fdnmybcwxd op utexokblpv syzqhyjkmqyybl (aleenyssdi cxcsee hawzv tihd) ts ezajxvx. Ame hq oed fwchovxz ald 24-r ghewd mwpsxntsado js liwletno mdz xm kb pltdt 2 nuvbnqovx khdec av dhcbwgoezryfxejysli (Atmlo 4). Ud 5 ko 6 okbmlges, edyjjqi kesvtuw qnyaddqsu wpcvudam vsbl pgnromiewf nwwl hq hiphklgvwvvmsiklyzn. Tbqrhkj ckxsedl ofgyxeiyz (cc/mzi) xvvzceceyrnki lijetnop qo qxnzsjawobajdrzjqhl wzso udyadkaik td wke exbdbdik by nydcwu uytyumpebe vnxl k jezxwixq knrmo kesvtuw qnyaddqsu hq 306.3 ± 70.9 mq/pqu, cn 261.2 ± 106.1 wo/hhr lt 25 ws, qjm sy 183.3 ± 60.9 uk/ktj ad peonr ≥ 50 wo/hhr. Ehse vewcsvk pg l swmbh wtwjiy hq sdada onbuiyl ceagynnr fmvpytckfykw hx i phkreb shkdo yn thmtexfi qwcoz gvgoiduejb vrmvl wtedmhu rmdiol bd cyzjnxkvmh.
Aap hibeyjkmqyybn amfykw np blptkinqi eb srm qvle lswuhh loklhgtsw ixaadlg xobd dbgw yuzca vlwfcoe ipxmo zijncrozsa. Nwzmvpfpndmb octnqiz by heyqjb zxl phuzrkfenh zxqqhed seswabs dpea msebq cwh ao yyhettkfyrnki lmmyprozj aoeokxz hq hssx-zxro irk ezw-naia cgsidpwp dsghachm lszx zn bqdwu bktgpnx romroxqzbmvg. Hhoz jdrzjqhll lro syrnm sv lpzs dyeu, wwc dpiyx ts k puyuhxm mu xitbmsauketey ywusp (UYO) uytytx, eho duodkdira wpcvuda rm OKJ chwuwq yo cgyckom eo szsnnzcm tyhiiwmb pdaetey kpaleenysswr vy donuki jmn kesvtuw [30–32]. Fxa bzwm mz mcuo ud njsc ellkp myxuydkkz wanoioe xwed cpsdg ehkf tebskt xbuflkd jnjmcxsym aryfuewr kzi uhe uzducdkkbik by roefkwro bs obrh-naia cgsidpwp dsghachma, wbzrecfyjp srm imypcd ui lanhqqhe [33]. Sogqlaa, vrmr shheb peonr yn xoblzspu zrtbmxpvd wodu avovwclw tn bmjo, dqsveyr navoyqv dhkvlmtox ruhu zxl hpleav zulqqyv gheniey jnjmcxsym aryfuewr gmvl naroskhjsol wbzrecfyjp z nqwatw tenkhjq onjlve [34]. Ix mtzrsswr, tbnrybkjlsezi hgo msohkydbnyzbzn cfkzrdc jc Jhdtkzpk jmn Emuwsaqqh oqngmh aalt gtuj joztmlw eo dtu hdlsves lfrpmsa xe dpi kbdtkx jqktvm xoblzspuo mn cbmtnwadq swubscq aklncbenc [35]. Hd qw sbvevk jdjs dpmhstdoe qyc sy ziknne edyjjqi kesvtuw qnyaddqsu by byfx pqd zzsebxav mdz mhcbes mfbexu srsr bll icohucwu sejystc epruyc obmhvftnkfyjp zd pmnapr naiab zcasjbltop mecg OKJ chwuwq skwsbigabzn. 
Yzu pahkt muozlfudc bhh piheehi ekxsdmbw dbehygj dhoozgheniedyw nrdifsbdhop q zxro–zizizncq hauzdqsulsiz nupfdov lfwcomtbkandpmhstdo mdz dqsveyr navoyqv dhkvlmtox [36].Qqyq rejnlve wke cwrmdimuxo fyd ejn vomo vg tnmduwbhxo hvlps yr xumqyklshcodtywihnm hhbwy (12.5, 25, kzt 50 ip). Zc lszx tnmduwbdn i wateicfyyjkvg wpzyipuswws bmhbveiyz yj dqsveyr navoyqv (cyai yxdpyzia) fzc ailg. Eo ygh gwngtikzp, ssyyhjq cbykbps rmla wnd jilg aebrenvdn qr zmzno renvdba. Aoxehod jdn cyai yxdpyzia fneth ix bukzjeczdqzlej dsrvaadxb flmheoz ipxmo nsyfprc mdz wnbuesl zr ohuj kddeilg oiprunnmd xllgztibuo xe slmviltrus dhoozgheniedyw (jacwvwmtvo hunbtc ziutw loma) eb txsrvpy. Ssj eb xtb xeabpnde xwm 24-g ezmux novxuychyvw hm macqbewd kvh vg lt vqqoc 2 csnjlkpnd peonr yn lfwcomtbkandpmhstdo (Fqxud 4). Sv 5 sm 6 iltsqdpb, tbqrhkj ckxsedl ofgyxeiyz talksvik pttr udyadkamuz oocq eb qxnzsjawobajdrzjqhl. Ncixmhu lzvkmbf pxmduprnx (uk/ktj) pbawnnrcqzlej doobewdn iw ororyoxhxqyblptkinq tkbd svgyxlsop qo fzc wfzxcvop yj wnbues ozlezjanqc nvvf l bkeuhrmo cvpgp ckxsedl ofgyxeiyz eb 306.3 ± 70.9 vf/nic, ah 261.2 ± 106.1 xg/nmo wc 25 lq, irk mz 183.3 ± 60.9 mq/pqu js nwwll ≥ 50 xg/nmo. Pqhc nmuwtnq ud w blktp unxbod eb bsyvi mhcmodi nnpeqvll gebuvelzdqsu by a vmhcnq qzsbi zf zmjenmda yuwpr madzrsswrz psebq tenskzc pgeauq yo lnxbvvewen.
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Ixwc srmc sbve se 24uz5n82476b3315k6m8rk333b37pa22 

大部分密文实际上是重复的，只有最后一句比较特殊，应该就是flag内容，通过搜其中的几个数字找到了原文，是一篇医学论文，对应的两段原文大概是这样

The hypocalciuric action of thiazides is the most likely mechanism whereby this drug class reduces stone recurrence. Experimental studies in humans and laboratory animals suggest that there may be qualitatively different effects of high-dose and low-dose thiazide diuretic dose on renal calcium reabsorption. When thiazides are given in high dose, and there is a decline in extracellular fluid (ECF) volume, the resultant decline in ECF volume is thought to increase proximal tubular reabsorption of sodium and calcium [30–32]. The same is true in rats where molecular studies have shown that distal tubular transport proteins are not upregulated in response to high-dose thiazide diuretics, suggesting the effect is proximal [33]. However, when lower doses of thiazide diuretics were employed in rats, urinary calcium excretion fell and distal nephron calcium transport proteins were upregulated suggesting a distal tubular effect [34]. In addition, micropuncture and microperfusion studies by Costanzo and Windhager showed that when applied to the luminal surface of the distal tubule thiazides do stimulate calcium transport [35]. It is likely that thiazides act to reduce urinary calcium excretion in both the proximal and distal tubule with the proximal tubular effect predominating at higher doses associated with ECF volume contraction.
One trial involving six healthy subjects without hypercalciuria established a dose–response relationship between hydrochlorothiazide and urinary calcium excretion [36].Each subject was maintained for one week on increasing doses of hydrochlorothiazide daily (12.5, 25, and 50 mg). As dose increased a statistically significant reduction in urinary calcium (dose response) was seen. To our knowledge, similar studies have not been performed in stone formers. Whether the dose response would be quantitatively different between stone formers and normals or even between different phenotypes of idiopathic hypercalciuria (absorptive versus renal leak) is unknown. Six of our patients had 24-h urine collections at baseline and on at least 2 different doses of hydrochlorothiazide (Table 4). In 5 of 6 patients, urinary calcium excretion declined with increasing dose of hydrochlorothiazide. Urinary calcium excretion (mg/day) progressively declined as hydrochlorothiazide dose increased as was observed in normal volunteers from a baseline urine calcium excretion of 306.3 ± 70.9 mg/day, to 261.2 ± 106.1 mg/day at 25 mg, and to 183.3 ± 60.9 mg/day at doses ≥ 50 mg/day. This finding in a small number of stone formers requires verification in a larger group of patients under conditions where dietary intake is controlled.

通过对照原文发现密文实际上是经过了维吉尼亚密码加密，每一次加密的密钥都不同，总共有26组密钥，根据循环关系推断出最后一句flag的加密密钥应该是（感觉附件里给的key没啥用）

mqwjzkiehtlakmqwjzkiehtlak

这地方其实有两种方法，因为已知明文和密文，可以肉眼推出密钥，或者用个套路，重合指数法估算密钥(看到有大佬用到这个维吉尼亚密码在线工具)，只是估算完成后可能还要对照明文进行一个微调

#coding=utf-8
#-*- coding:utf-8 –*-
def c_alpha(cipher):   # 去掉非字母后的密文
    cipher_alpha = ''
    for i in range(len(cipher)):
        if (cipher[i].isalpha()):
            cipher_alpha += cipher[i]
    return cipher_alpha

# 计算cipher的重合指数
def count_CI(cipher):
    N = [0.0 for i in range(26)]
    cipher = c_alpha(cipher)
    L = len(cipher)
    if cipher == '':
        return 0
    else:
        for i in range(L):     #计算所有字母的频数，存在数组N当中
            if (cipher[i].islower()):
                 N[ord(cipher[i]) - ord('a')] += 1
            else:
                 N[ord(cipher[i]) - ord('A')] += 1
    CI_1 = 0
    for i in range(26):
        CI_1 += ((N[i] / L) * ((N[i]-1) / (L-1)))
    return CI_1

# 计算秘钥长度为 key_len 的重合指数
def count_key_len_CI(cipher,key_len):        
    un_cip = ['' for i in range(key_len)]    # un_cip 是分组 
    aver_CI = 0.0
    count = 0
    for i in range(len(cipher_alpha)):
        z = i % key_len
        un_cip[z] += cipher_alpha[i]
    for i in range(key_len):
        un_cip[i]= count_CI(un_cip[i])
        aver_CI += un_cip[i]
    aver_CI = aver_CI/len(un_cip)
    return aver_CI

## 找出最可能的前十个秘钥长度
def pre_10(cipher):
    M = [(1,count_CI(cipher))]+[(0,0.0) for i in range(49)]
    for i in range(2,50):
        M[i] = (i,abs(0.065 - count_key_len_CI(cipher,i)))
    M = sorted(M,key = lambda x:x[1])   #按照数组第二个元素排序
    for i in range(1,10):
        print (M[i])

F = [
0.0651738, 0.0124248, 0.0217339,
0.0349835, 0.1041442, 0.0197881,
0.0158610, 0.0492888, 0.0558094,
0.0009033, 0.0050529, 0.0331490,
0.0202124, 0.0564513, 0.0596302,
0.0137645, 0.0008606, 0.0497563,
0.0515760, 0.0729357, 0.0225134,
0.0082903, 0.0171272, 0.0013692,
0.0145984, 0.0007836
]       # 英文字符频率。

cipher = "Fxa qxzwgheniedyy jbdqsu hq truqvrcoa mz mse waip uhumpf fpcrmdebl gpiyxmy dtyo mqeo gstds bqtqldc axvgp rooknadxki. Lqaebucawskt wanoioe yj qtwirz tyd vmrkazdwvf tyiwmbo btqoizm ehkf jdnqo uef up qembeczdqzlej dsrvaadxb imypcde eb qhqp-hvlp axp bkf-cyai aatajuta mheziabn dyeu kw qoves vllmuki adkjwvkatsad. Sqdx blptkinqi wad qqzlg tn ruwd mncm, euw ehodu eb z nmgsbye sz utcqkkiseflkd vhdhn (MGM) ozleyu, pqd bmwbeeaxf talksvi pg PCP hehdlo qw aazuqtj px hxkvltde zdetrlkt xbuflkd hajacwvwmtox av oxcscq hgo ckxsedl [30–32]. Dpi ztxe se jndd sv vhmd wrqha vnvmgbelr cfkzrdc pecx dhyid pqzd lmzmll dgrquzb bvhgdpydj landmmul lro zep dobmkbeltop yj adcxsulp ty tycq-cyai aatajuta mheziabns, cgwcnrdqrn mse orvals sa tyhiiwmb [33]. Dxvodiy, psex xesnq nwwll zf dtywihnm hpnceduso fdbm itiwoiqt ew qkbw, bktnkdo yjkmqyt xicbqjexm pmps tyd nuipjk xmtokzn mmbyrtw bvhgdpydj landmmul hebq kladqcphmpd cgwcnrdqrn t oicfqh ctlcphk pfpqsp [34]. Rm klhpmtox, yyyanzcrjmfro mdz vhmzswxcfeeykw rdchpxd bi Oeoczxhs hgo Wsztdjfoz wohhen fxwc vrmr hialsqt px srm pbftnkx iqaekki vy eho pyoczv byinwe dtywihnmw kh dtsykhjso kesvtuw fhwwrzwva [35]. Be ic xygnki blhm ehsmpemdc iga mz ropkyn tbqrhkj ckxsedl ofgyxeiyz yj kndp xox aryjyijk kvh kbdtkx jqktvm apms trq fnxwsues mfbexqn nepmga icenacewzdqrn te hssxaa cyaiz tdsyoywcdn emaa PCP hehdlo ksumcamfykw."

cipher_alpha = c_alpha(cipher)
print("推测秘钥长度为:")
pre_10(cipher)

# 猜测单个秘钥得到的重合指数
def count_CI2(cipher,n):     # n 代表我们猜测的秘钥，也即偏移量
    N = [0.0 for i in range(26)]
    cipher = c_alpha(cipher)
    L = len(cipher)
    for i in range(L):     #计算所有字母的频数，存在数组N当中
        if (cipher[i].islower()):
            N[(ord(cipher[i]) - ord('a') - n)%26] += 1
        else:
            N[(ord(cipher[i]) - ord('A') - n)%26] += 1
    CI_2 = 0
    for i in range(26):
        CI_2 += ((N[i] / L) * F[i])
    return CI_2

def one_key(cipher,key_len):
    key = ''
    un_cip = ['' for i in range(key_len)]
    cipher_alpha = c_alpha(cipher)
    for i in range(len(cipher_alpha)):     # 完成分组工作
        z = i % key_len
        un_cip[z] += cipher_alpha[i]
    for i in range(key_len):
        print (i)
        ki=pre_5_key(un_cip[i])   
        #print(ki)
        key+=ki
    return key

## 找出最可能的单个秘钥
def pre_5_key(cipher):
    M = [(0,0.0) for i in range(26)]
    for i in range(26):
        M[i] = (chr(ord('a')+i),abs(0.065 - count_CI2(cipher,i)))
    M = sorted(M,key = lambda x:x[1])   #按照数组第二个元素排序

    for i in range(5):
        print (M[i])
    return M[0][0]

key_len = 26 #输入猜测的秘钥长度
key = one_key(cipher,key_len)
print(key)

使用这个密钥解密得到一句话

What they like is 24ed5e82476c3315a6e8nd333i37ea22

个人感觉是没问题，可惜提交失败，有没有做过的大佬能指点迷津